Sir,

The taxane class of drugs (eg, paclitaxel (Taxol), paclitaxel nanoparticle albumin bound (NAB) (Abraxane), docetaxel (Taxotere)) are microtubule-stabilizing agents that are used to treat numerous malignancies. Cystoid macular oedema (CME) without increased permeability is a rare side effect of these medications.1, 2, 3 In the following report, non-leaking CME secondary to paclitaxel–NAB was successfully treated with off-label use of topical 2% dorzolamide (Trusopt) in conjunction with cessation of the chemotherapy agent. A monocular treatment trial suggested more rapid resolution with dorzolamide compared with drug cessation alone.

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