Autologous plasma eyedrops prepared in a closed system: a treatment for dry eye

Sir,

Autologous serum (AS; 20–50%) has been used as a tear substitute for severe dry eye patients. Protocols for preparation of AS are available^{1, 2, 3} but there is no universally accepted methodology, which hinders regulatory approval and widespread clinical use. Here, we report an approach that utilizes 100% autologous plasma (AP) directly from plasmapheresis, which minimizes contamination. In this ‘closed’ system, plasma collected is directly portioned into single-use segments within tubings.

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