Increased corneal densitometry as a subclinical corneal change associated with multiple myeloma

Sir,

Multiple myeloma (MM) is a malignant plasma cell disorder of the bone marrow characterized by high levels of monoclonal serum protein and multiple organ involvement.¹ Corneal crystalline deposition is a rarely reported but known ocular manifestation of MM.² Recent reports have employed in vivo confocal microscopy (IVCM) to investigate MM-associated crystalline deposits.^{3, 4, 5} However, the pathophysiology of this condition is not fully understood. To objectively quantify the MM-associated corneal changes in differing depths of the cornea, we obtained corneal densitometry data in MM patients using a Scheimpflug camera. A hypothesis for the pathogenesis of this condition is discussed.

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