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Glioblastoma

Microvesicles as major biomarkers?

Nature Reviews Cancer volume 13, page 8 (2013)Cite this article

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Microvesicles are membrane-bound vesicles shed by numerous cell types that contain various plasma membrane proteins (and other biomolecules) that are characteristic of the cell of origin. Hakho Lee, Ralph Weissleder and colleagues adapted a method of microvesicle detection that they had previously devised for whole-cell analysis. It involves immuno-magnetic labelling and micro-nuclear magnetic resonance (μNMR) detection. For ease of clinical application, a microfluidic device was developed that can label microvesicles with antibody-bound magnetic nanoparticles (MNPs), filter out unbound antibodies or MNPs on the basis of particle size, and can detect labelled microvesicles using an integrated microcoil.

more sensitive than other detection methods

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ORIGINAL RESEARCH PAPER

  1. Shao, H. et al. Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nature Med. 11 Nov 2012 (doi:10.1038/nm.2994)

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Authors
  1. Darren J. Burgess
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Burgess, D. Microvesicles as major biomarkers?. Nat Rev Cancer 13, 8 (2013). https://doi.org/10.1038/nrc3424

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