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Organelle dynamics

Inheritance for pluripotency

Nature Reviews Molecular Cell Biology volume 12, page 691 (2011)Cite this article

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Using a fluorescent midbody marker, the authors first observed the fate of MBds in different cultured cell types and found that they accumulated in some cells but not others. By also visualizing centrosomes, they showed that the inherited MBds associated with the daughter cell containing the older centrosome.

Next, they determined the localization of MBds in human and mouse tissues. They found that MBds accumulated within stem cell niches, such as the basal compartment of seminiferous tubules of testes and the subventricular zone of mouse embryo brains. This indicates that MBds are retained and accumulate in stem cells in vivo. To further test this theory, the authors examined the fate of MBds during somatic cell reprogramming and stem cell differentiation in vitro. As expected, MBds were lost on differentiation of human embryonic stem cells to fibroblasts and, consistently, MBds accumulated in induced pluripotent stem (iPS) cells generated from fibroblasts.

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ORIGINAL RESEARCH PAPER

  1. Kuo, T.-C. et al. Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nature Cell Biol. 13, 1214–1223 (2011)

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  1. Kim Baumann
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Baumann, K. Inheritance for pluripotency. Nat Rev Mol Cell Biol 12, 691 (2011). https://doi.org/10.1038/nrm3216

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