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An exit strategy for the tubercle bacillus?

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References

  1. Hybiske, K. & Stephens, R. S. Exit strategies of intracellular pathogens. Nature Rev. Microbiol. 6, 99–110 (2008).

    Article  CAS  Google Scholar 

  2. Volkman, H. E. et al. Tuberculous granuloma formation is enhanced by a mycobacterium virulence determinant. PLoS Biol. 2, e367 (2004).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Kaku, T., Kawamura, I., Uchiyama, R., Kurenuma, T. & Mitsuyama, M. RD1 region in mycobacterial genome is involved in the induction of necrosis in infected RAW264 cells via mitochondrial membrane damage and ATP depletion. FEMS Microbiol. Lett. 274, 189–195 (2007).

    Article  CAS  PubMed  Google Scholar 

  4. Hsu, T. et al. The primary mechanism of attenuation of bacillus Calmette–Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc. Natl Acad. Sci. USA 100, 12420–12425 (2003).

    Article  CAS  Google Scholar 

  5. Sherman, D. R. et al. Mycobacterium tuberculosis H37Rv: Delta RD1 is more virulent than M. bovis bacille Calmette–Guerin in long-term murine infection. J. Infect. Dis. 190, 123–126 (2004).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Stanley, S. A., Raghavan, S., Hwang, W. W. & Cox, J. S. Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system. Proc. Natl Acad. Sci. USA 100, 13001–13006 (2003).

    Article  CAS  Google Scholar 

  7. Pym, A. S., Brodin, P., Brosch, R., Huerre, M. & Cole, S. T. Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. Mol. Microbiol. 46, 709–717 (2002).

    Article  CAS  Google Scholar 

  8. Guinn, K. M. et al. Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis. Mol. Microbiol. 51, 359–370 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Hingley-Wilson, S., Lalvani, A. An exit strategy for the tubercle bacillus?. Nat Rev Microbiol 6, 954 (2008). https://doi.org/10.1038/nrmicro1821-c1

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