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Clinical trials

Cardiovascular benefits of paricalcitol in chronic kidney disease

Nature Reviews Nephrology volume 10, page 675 (2014)Cite this article

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Beneficial effects of vitamin D analogues on cardiovascular outcomes in the chronic kidney disease (CKD) population have been elusive. In the first randomized controlled trial of its kind, researchers now show that an active vitamin D analogue can exert a positive effect on the cardiovascular system of patients with CKD.

The Paricalcitol and Endothelial Function in Chronic Kidney Disease (PENNY) trial analysed the effects of paricalcitol on flow-mediated dilation (FMD), in 88 patients with stage 3–4 CKD and parathyroid hormone levels >65 ng/l.

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References

  1. Zoccali, C. et al. Paricalcitol and endothelial function in chronic kidney disease trial. Hypertension 64, 1005–1011 (2014)

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  1. Jessica K. Edwards
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Edwards, J. Cardiovascular benefits of paricalcitol in chronic kidney disease. Nat Rev Nephrol 10, 675 (2014). https://doi.org/10.1038/nrneph.2014.200

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