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A population-based study on association of iridocyclitis with Sjogren’s syndrome

Eye volume 39, pages 1643–1645 (2025)Cite this article

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Sjögren’s syndrome, also known as Sjögren’s disease (SjD), is a chronic autoimmune disorder affecting the exocrine glands. This systemic autoimmune disorder, characterized by dry eyes and mouth, has been extensively studied for its association with various ocular conditions [1, 2]. Besides the commonly mentioned dry eye, little has been explored regarding other ocular manifestations, such as uveitis and iridocyclitis. Similarly, with an autoimmune-driven nature, iridocyclitis has been reported to be related to underlying immune disorders [3, 4]. However, the link between SjD and iridocyclitis remains inadequately explored, particularly in large-scale population studies. This study aimed to explore the association of iridocyclitis with previously diagnosed SjD by a population-based dataset.

This case-control study utilized data from the Taiwan LHID2010. The Research Ethics Committee of Taipei Medical University (TMU JIRB N202308031) granted approval for the study. We have included 15,626 patients who are ≥20 years of age and have received a first-time diagnosis of Iridocyclitis (ICD-9-CM Code 364.00~364.02, 364.3 or ICD-10-CM codes H20, H21) between 2013 and 2019. We considered the date of the initial Iridocyclitis diagnosis as the index date.

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Data availability

The LHID2010 that supports the findings of this study can be reached by researchers through a formal application process addressed to the HWDC, Department of Statistics, Ministry of Health and Welfare, Taiwan (https://dep.mohw.gov.tw/DOS/cp-5119-59201-113.html).

References

  1. Akpek EK, Bunya VY, Saldanha IJ. Sjögren’s syndrome: more than just dry eye. Cornea. 2019;38:658–61.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Oszkowska AM, Oliverio GW, Aragona E, Inferrera L, Severo AA, Alessandrello F, et al. Ophthalmologic manifestations of primary Sjögren’s syndrome. Genes. 2021;12:365.

    Article  Google Scholar 

  3. Van Gelder RN. Idiopathic no more: clues to the pathogenesis of Fuchs heterochromic iridocyclitis and glaucomatocyclitic crisis. Am J Ophthalmol. 2008;145:769–71.

    Article  PubMed  Google Scholar 

  4. Montalvo KGC, Soria CJD, Vizcaíno KJL, Cárdenas LSV. Uveitis as an ophthalmologic manifestation of autoimmune diseases: a detailed analysis of the clinical implications. Rev Cient Interdiscip Investig Saberes. 2024;14:62–81.

    Google Scholar 

  5. Bridges AJ, Burns RP. Acute iritis associated with primary sjögren’s syndrome and high-titer anti—SS-A/Ro and anti—SS-B/La antibodies. Treatment with combination immunosuppressive therapy. Arthritis Rheum. 1992;35:560–3.

    Article  CAS  PubMed  Google Scholar 

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Author notes

  1. These authors contributed equally: Jau-Der Ho, Hsin-Chien Lee, Shih-Han Hung, Tsai-Ching Liu, Herng-Ching Lin.

Authors and Affiliations

  1. School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan

    Hsin-Yu Lu & Herng-Ching Lin

  2. Department of Ophthalmology, Taipei Medical University Hospital, Taipei, Taiwan

    Hsin-Yu Lu & Jau-Der Ho

  3. Graudate Institute of Humanities in Medicine, College of Humanities & Social Sciences, Taipei Medical University, Taipei, Taiwan

    Hsin-Chien Lee

  4. Department of Psychiatry & Sleep Center, Taipei Medical University Hospital, Taipei, Taiwan

    Hsin-Chien Lee

  5. Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei, Taiwan

    Shih-Han Hung

  6. International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    Shih-Han Hung

  7. Department of Public Finance, Public Finance and Finance Research Center, National Taipei University, New Taipei City, Taiwan

    Tsai-Ching Liu

  8. Research Center of Data Science on Healthcare Industry, College of Management, Taipei Medical University, Taipei, Taiwan

    Tsai-Ching Liu

  9. Research Center of Sleep Medicine, Taipei Medical University Hospital, Taipei, Taiwan

    Herng-Ching Lin

Authors
  1. Hsin-Yu Lu
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  2. Jau-Der Ho
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  3. Hsin-Chien Lee
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  4. Shih-Han Hung
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Contributions

Conceptualization: HC Lin and HY; Data curation: TC; Formal analysis: TC and HC Lin; Methodology: HY, TC and HC; Writing – original draft: HY, JD, HC Lee, SH, TC, and HC Lin; Writing - review & editing: SH; Review and approval of final manuscript: HY, JD, HC Lee, SH, TC, and HC Lin.

Corresponding authors

Correspondence to Tsai-Ching Liu or Herng-Ching Lin.

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The authors declare no competing interests.

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Lu, HY., Ho, JD., Lee, HC. et al. A population-based study on association of iridocyclitis with Sjogren’s syndrome. Eye 39, 1643–1645 (2025). https://doi.org/10.1038/s41433-025-03798-y

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