Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

Comment on: Significance of serum biomarkers in preterm infants screened for retinopathy of prematurity: a systematic review and meta-analysis

Eye (2026)Cite this article

Subjects

Dear Editor,

Chuang et al. [1] performed a systematic review and meta-analysis to investigate the relationship between eight serum biomarkers and the occurrence of retinopathy of prematurity (ROP) in preterm infants. However, several aspects require further clarification.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Chuang SH, Le YTT, Li YH, Chang CH, Lian YZ, Kuo YJ, et al. Significance of serum biomarkers in preterm infants screened for retinopathy of prematurity: a systematic review and meta-analysis. Eye. 2025;39:3167–75.

    Article  CAS  PubMed  Google Scholar 

  2. Oruz O, Dervişoğulları MS, Öktem ME, İncekaş C. Predictive role of systemic immune-inflammation index and neutrophil/lymphocyte ratio values in infants with retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol. 2024;262:3125–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Obata S, Matsumoto R, Kakinoki M, Sawada O, Sawada T, Saishin Y, et al. Blood neutrophil-to-lymphocyte ratio as a risk factor in treatment for retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol. 2023;261:951–7.

    Article  CAS  PubMed  Google Scholar 

  4. Borțea CI, Stoica F, Boia M, Iacob ER, Dinu M, Iacob R, et al. Risk factors associated with retinopathy of prematurity in very and extremely preterm infants. Medicina. 2021;57:420.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Shenyang Fourth People’s Hospital, Shenyang, Liaoning, China

    Ling Chen

Authors
  1. Ling Chen
    View author publications

    Search author on:PubMed Google Scholar

Contributions

Ling Chen: Conceptualisation; Ling Chen: Methodology and critically revise this manuscript; Ling Chen – review & editing, Writing – original draft.

Corresponding author

Correspondence to Ling Chen.

Ethics declarations

Competing interests

The author declares no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, L. Comment on: Significance of serum biomarkers in preterm infants screened for retinopathy of prematurity: a systematic review and meta-analysis. Eye (2026). https://doi.org/10.1038/s41433-026-04244-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Version of record:

  • DOI: https://doi.org/10.1038/s41433-026-04244-3

Search

Advanced search

Quick links