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An initial investigation into changes in post-transplant serum testosterone levels in men undergoing lung transplantation: what are the take aways?

International Journal of Impotence Research volume 37, page 680 (2025)Cite this article

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In this pilot study, the authors evaluated serum testosterone level changes in men undergoing lung transplantation using the TriNetX Research Network [1]. They identified 51 men without confounding testosterone use who were divided into low and normal testosterone levels prior to transplant. They noted that after transplantation, there was an increase in testosterone levels that failed to reach statistical significance.

The perioperative hormonal changes that are associated with solid organ transplants are understudied and of interest to the transplant and sexual medicine communities [2]. Moreover, as the authors note, lung transplantation is the fourth most common solid organ transplant performed in the United States yet is understudied in regards to hormonal kinetics.

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References

  1. Thompson A, Omil-Lima D, Perez J, Jesse E, Gupta K, Khera M, et al. Changes in post-transplant serum testosterone levels in men undergoing lung transplantation: a pilot study using the TriNetX Research Network. Int J Impot Res. 2024. https://doi.org/10.1038/s41443-024-00921-7.

  2. Omil-Lima D, Jesse E, Gupta K, Sellke N, Muncey W, Burrelli C, et al. Testosterone deficiency in male organ transplant recipients. Int J Impot Res. 2022;34:679–84. https://doi.org/10.1038/s41443-021-00513-9.

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  3. Shoskes DA, Kerr H, Askar M, Goldfarb DA, Schold J. Low testosterone at time of transplantation is independently associated with poor patient and graft survival in male renal transplant recipients. J Urol. 2014;192:1168–71.

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  1. College of Medicine, University of Florida, Gainesville, FL, USA

    Kevin Campbell

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  1. Kevin Campbell
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Correspondence to Kevin Campbell.

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Campbell, K. An initial investigation into changes in post-transplant serum testosterone levels in men undergoing lung transplantation: what are the take aways?. Int J Impot Res 37, 680 (2025). https://doi.org/10.1038/s41443-024-00956-w

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