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Understanding treatment options in craniopharyngioma better

Nature Reviews Disease Primers volume 6, Article number: 28 (2020) Cite this article

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As the most extensive review on Craniopharyngioma in recent years, I was pleased to see a description of the clinical and research work on this important disease (Müller, H. L., Merchant, T. E., Warmuth-Metz, M., Martinez-Barbera, J. P. & Puget, S. Craniopharyngioma. Nat. Rev. Dis. Primers 5, 75 (2019))1. However, the research community is increasingly optimistic about treatment outcomes in craniopharyngioma despite it having been described as an incurable and irresectable, albeit benign, tumour2. Accordingly, it is necessary and meaningful to comment on some of the controversies underlying these different views.

The essential characteristic of the benign cellular behaviour of craniopharyngioma3 is the relationship between the tumour and the adjacent nervous tissue, especially the hypothalamus but also the neurohypophysis and pituitary stalk4,5. The tumour displaces the hypothalamus through invagination6,7 rather than infiltration, leading to an inflammatory reaction and gliosis mediated by microglial proliferation. Three patterns regarding the relationship between tumour and the third ventricular floor were identified based on our research: mantle-like, moat-like and mortise-like. To ensure safe surgical resection and avoid severe hypothalamic injury3, understanding the pattern of gliosis is essential. Müller et al.1 proposed preoperative grading of the hypothalamic involvement using preoperative images, which can mistakenly reflect the interplane of tumour to nervous tissue. For example, different tumours might appear similar on imaging, but their underlying relationship with the hypothalamus may be different3; accordingly, understanding this relationship is essential to protect the hypothalamus during surgery. Conservative surgical therapy with adjuvant radiotherapy is supported widely by the field generally. This conservative approach contrasts with reports from a few clinical centres, in which gross total resection of tumour was associated with significantly improved quality of life8.

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References

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Acknowledgements

The author is supported by the Chinese National Natural Science Fund (81972355 and 81972352), National Key Clinical Specialty Project, and the Research Foundation of the Chinese Society of Neuro-oncology (CSNO-2016-MSD20). The author thanks Y. Lu, Y. Liu, Y. Bao and C. Wang (Department of Neurosurgery, and Nanfang Neurology Research Institution, Nanfang Hospital, Southern Medical University, Guangzhou, China) for preparing background information for this letter.

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  1. Department of Neurosurgery, and Nanfang Neurology Research Institution, Nanfang Hospital, Southern Medical University, Guangzhou, China

    Songtao Qi

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Qi, S. Understanding treatment options in craniopharyngioma better. Nat Rev Dis Primers 6, 28 (2020). https://doi.org/10.1038/s41572-020-0173-1

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