Table 2 Evolution of prognostic factors in Wilms tumour studies in the NWTS Group and the COG

NWTS-1

Stage

–

–

–

–

–

–

–

–

–

–

–

^17,41

NWTS-2

Stage

–

–

–

–

–

–

–

–

–

–

^18,115

NWTS-3

Stage

Histology

–

–

–

–

–

–

–

–

–

–

^19,51

NWTS-4

Stage

Histology

–

–

–

–

–

–

–

–

–

–

^20,28,116

NWTS-5

Stage

Histology

Age

Tumour nephrectomy weight

–

–

–

–

–

–

–

–

^{5,14,21,42,65}

COG first-generation studies (AREN0321, 0532, 0533, 0534)

Stage

Histology

Age

Tumour nephrectomy weight

LOH of 1p and 16q

Lung metastatic response

Extrapulmonary metastases

Bilateral/predisposition

Post-chemotherapy histology (bilateral/predisposed only)

−

–

–

^{7,8,9,11,27,47}

COG second-generation studies (AREN2231, to be decided)

Stage

Histology^a

Age^b

 –

LOH of 1p and/or 16q

Lung metastatic response

Extrapulmonary metastases

Bilateral/predisposition

Post-chemotherapy histology (all)

LOH 11p15^c

1q gain

Lymph node involvement

–