Fig. 2: β-arrestin 2 recruitment profiles of GIPR non-synonymous variants. | Nature Metabolism

Fig. 2: β-arrestin 2 recruitment profiles of GIPR non-synonymous variants.

From: Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

Fig. 2

a, β-arrestin 2 recruitment potency (logEC50) of GIP. Variants are arranged according to cAMP efficacy of 100 pM GIP. b, β-arrestin 2 recruitment maximal signalling (Emax), shown as a percentage of WT GIPR activity. NA, no activation. c, Dose-response curves of cAMP production (left) and β-arrestin 2 recruitment (right) of GIPR variants R12Q, I221M, M67R and S64P, respectively. Data represents the mean ± s.e.m. WT GIPR: N = 30; R12Q–S64P, Y73H–C84P, V99I–T168A, A185V, P195R: N = 5; M67R: N = 6; W90L, R183Q, A207V, R336P–E354Q: N = 4; R190Q, E288G: N = 6; I221M–L261H, E291K–L304R, I378M–E463Q: N = 3. Independent experiments were performed in duplicate.

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