Extended Data Fig. 3: Internalization abilities of the eight LoFcAMP/WT-likearr variants and two LoFcAMP/LoFarr. | Nature Metabolism

Extended Data Fig. 3: Internalization abilities of the eight LoFcAMP/WT-likearr variants and two LoFcAMP/LoFarr.

From: Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

Extended Data Fig. 3

a, The donor signal represents an estimate of receptor surface expression of the cells transfected with SNAP-WT GIPR or variants. N = 4. b, Internalization ratios of the SNAP-GIPR variants over time following stimulation with GIP in doses ranging from 1 nM to 1 µM. N = 4. c, Area under the curves of the SNAP-WT GIPR vs. SNAP-GIPR variants in response to GIP stimulation in doses ranging from 1 nM to 1 µM. N = 4. d, Dose-response curves of maximal internalization of the SNAP-GIPR variants, shown as percentage of maximal SNAP-WT GIPR internalization. N = 4. Data are shown as the mean ± s.e.m. Independent experiments were performed in triplicates.

Source data

Back to article page