Extended Data Fig. 4: Burden association of the GIPR variant groups on cardiometabolic phenotypes in the Danish cohorts. | Nature Metabolism

Extended Data Fig. 4: Burden association of the GIPR variant groups on cardiometabolic phenotypes in the Danish cohorts.

From: Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

Extended Data Fig. 4

Forest plot showing burden test statistics in the Danish population (Inter99). NC, number of individuals for each phenotype carrying any of the variants within that variant group. NN-C, number of individuals not carrying any of the variants within that variant group. q, false discovery rate (FDR) adjusted p-values of the burden tests (performed using SKAT/SKAT-O). pLoF denotes variants predicted to cause loss of function with VEP. pLoF variants were not functionally characterized but include some of the LoFcAMP/LoFarr variants. The E354Q variant was excluded from burden testing of the WT-likecAMP/WT-likearr group due to high minor allele frequency (MAF; ~20%). Beta and error bars represent effect size as standard deviation and the 95% confidence interval, respectively, derived from a linear model.

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