Extended Data Fig. 5: mRNA and protein expression levels of the 27 genes/proteins corresponding to the 33 sites predicted by pFunK.
From: Ketogenic diet reshapes cancer metabolism through lysine β-hydroxybutyrylation
a Transcript expression level of the 27 genes in Ctrl and KD mice. b Protein expression level of the 27 proteins in Ctrl and KD mice. c The GSEA analysis of the 5,304 Kbhb sites ranked by pFunK scores. Enriched pathways were indicated (p < 0.05, q < 0.25). d The protein expression levels of Aldob, Aldoa, and Aldoc in livers of KD and Ctrl mice, indicated by normalized intensity values. e The mRNA expression levels of ALDOB, ALDOA, and ALDOC in livers of KD and Ctrl mice, indicated by normalized expression values. f The word cloud analysis of GO biological process terms for the 27 proteins harboring at least one predicted functional Kbhb site. g, h The LC/MS-MS analysis of BDH1-derived peptides containing β-hydroxybutyrylated K91 (g) and K97 (h).
