Fig. 1: GWAS discovery for eight BCF traits identifies 55 significant associations. | Nature Metabolism

Fig. 1: GWAS discovery for eight BCF traits identifies 55 significant associations.

From: Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology

Fig. 1

a, Overview of the signal discovery strategy. We mapped genetic effects on BCF indices using oral glucose-stimulated and steady-state fasting measurements from ~26,000 non-diabetic individuals. In-house BCF groupings are highlighted on the right. b. Multi-trait Manhattan plot of single-variant genome-wide association meta-analyses for eight BCF estimates. From inner to outer tracks: HOMA-β, DI, DIBIG, BIGTT-AIR, CIR, Stumvoll, xinsdG30 and xinsG30. Genome-wide significant variants (P ≤ 5 × 10−8) are coloured in dark blue and previously unreported loci are in red. Loci meeting Bonferroni-correction thresholds are detailed in Supplementary Table 3. Y axis, association P-values on the –log10 scale; x axis, genomic position in hg19.

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