Fig. 2: Impact of BCF loci on other complex traits.
a, Heatmap of genetic correlations (Z-score) between each BCF trait and other complex traits, as calculated by LDSC regression implemented in LDHub. Asterisks indicate significant correlations after Bonferroni multiple-test correction (P ≤ 0.05 / (8 BCF traits × 9 complex trait categories)). Rows are grouped using hierarchical clustering with Euclidean distance. b, Effect sizes (Z-scores) for multiple pancreatic islet-relevant traits among 42 BCF loci. Loci are named as follows: gene | chromosome:position [effect allele]. WHR, waist-to-hip ratio; IFC, insulin fold change; ISI, Stumvoll insulin sensitivity; T1D, type 1 diabetes; IVGTT, intravenous glucose tolerance test; MRI, magnetic resonance imaging; Kidney function, estimated glomerular filtration rate based on serum creatinine; TG, triglycerides. Variant effect sizes were aligned to a negative BIGTT-AIR effect. The sentinel variant at each locus corresponds to the lead variant or a proxy (LD r2 > 0.7), excluding non-palindromic alleles and with available data among all BCF, BMI and T2D traits. **Genome-wide significant (P ≤ 5 × 10−8), *Bonferroni-corrected P-value (P ≤ 0.05 / 42 variants), | Nominal significance (P ≤ 0.05). Red, yellow and blue dots on the left indicate moderate evidence of colocalization at a given BCF locus between at least one BCF trait and T2D, fasting glucose or BMI, respectively.
