Extended Data Fig. 1: Genome-wide association meta-analyses for eight β-cell function (BCF) estimates. | Nature Metabolism

Extended Data Fig. 1: Genome-wide association meta-analyses for eight β-cell function (BCF) estimates.

From: Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology

Extended Data Fig. 1

Manhattan plots (a) and q-q plots (b) using summary statistics of eight single-variant BCF GWAS meta-analyses in up to 26,000 individuals. (a) For each variant tested, association P-values on -log10 scale (y-axis) are plotted against their genomic locations in hg19 (x-axis). The black horizontal line denotes genome-wide significance, P-value ≤ 5x10−8. (b) Observed -log10 (P-values) are compared against expected -log10 (P-values) according to a uniform distribution. Significant loci after Bonferroni multiple-test correction can be found in Supplementary Table 3.

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