Extended Data Fig. 3: BMI influence on β-cell function (BCF) loci. | Nature Metabolism

Extended Data Fig. 3: BMI influence on β-cell function (BCF) loci.

From: Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology

Extended Data Fig. 3

BMI influence on BCF-loci for (a) xinsG30, (b) xinsdG30, (c) CIR, (d) Stumvoll, (e) DI, and (f) HOMA-β. Each panel includes Miami plots showing -log10 association P-values with and without BMI-adjustment on the y-axis. Chromosome and genome locations in hg19 are provided on the x-axis. Variants that reached genome-wide significance (P-value ≤ 5x10-8) (indicated by orange dots) were tested for heterogeneity (two-sided P-values) of the effect sizes (right panel). Significant heterogeneous variants are coloured red. The right panel compares effect sizes (Z-scores) without and with BMI-adjustment (x and y-axis, respectively). The -log10 P-values from the heterogeneity test are used as the colouring scheme, with significant heterogeneous loci labelled by the nearest gene. The significance threshold was Bonferroni-adjusted for the number of independent loci (P-value < 0.05 / 55).

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