Extended Data Fig. 4: Pleiotropic genetic effects between β-cell function (BCF) loci and other relevant traits and diseases.
(a) Heatmap representations show colocalization posterior probabilities from COLOC between each BCF trait and T2D, FG and BMI for 44 BCF loci. Heatmap colours indicate the strength of a shared causal variant hypothesis H4 between each combination of traits being examined. Grouping of BCF loci on the left follows Fig. 2b. (b-c) Insulin sensitivity effects on BCF were assessed by testing (two-sided P-values) for heterogeneity in effect sizes (as Z-scores) among genome-wide significant variants between (b) DI (x-axis) and xinsG30 (y-axis), and (c) DIBIG (x-axis) and BIGTT-AIR (y-axis). The colour legend indicates the -log10 (P-value) of the heterogeneity test estimate. Significant heterogeneous loci are labelled by the nearest gene. The significance threshold was adjusted by the number of independent loci using Bonferroni correction (P-value < 0.05 / 55).
