Extended Data Fig. 5: Epigenomic datasets and chromatin interaction maps in human pancreatic islets connect non-coding β-cell function (BCF) genetic associations with (a) SSTR1 and (b) SSTR2 genes. | Nature Metabolism

Extended Data Fig. 5: Epigenomic datasets and chromatin interaction maps in human pancreatic islets connect non-coding β-cell function (BCF) genetic associations with (a) SSTR1 and (b) SSTR2 genes.

From: Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology

Extended Data Fig. 5

Regional signal plots show P-values calculated from single-variant BCF GWAS meta-analyses on a -log10 scale (y-axis) across the hg19 genome build (x-axis). Variants are coloured according to their LD correlation (r2) with the lead association. Epigenomic datasets in human pancreatic islets, including chromatin accessibility, histone modifications and TF binding profiles, are shown along with enhancer-gene assignments from pcHi-C. Fine-mapped enhancer variants connected to each molecular effector gene are highlighted with circles coloured according to their LD (r2) with the lead association in the locuszoom plot.

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