Extended Data Fig. 6: ACLY's Role in Mitigating Stress is Linked to Dietary Carbohydrates. | Nature Metabolism

Extended Data Fig. 6: ACLY's Role in Mitigating Stress is Linked to Dietary Carbohydrates.

From: Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress

Extended Data Fig. 6

a. RT-PCR analysis of Atf4 in the AclyBATKO mice 2 and 4 week of age. *p=0.0496. 2W: n=5 C, 5 KO; 4W: n=6 C, 6 KO. b. RT-PCR analysis of Ucp1 in the AclyBATKO mice 2 and 4 week of age. *p=0.0106. c. RT-PCR analysis of Acss2 in the AclyBATKO mice 2 and 4 week of age. *p=0.0110, p*=0.0110, *p=0.0145. d. RT-PCR analysis of Fasn in the AclyBATKO mice 2 and 4 week of age.****p<0.0001, ***p=0.0001. e. RT-PCR analysis of Chrebpa in the AclyBATKO mice 2 and 4 week of age. ****p<0.0001, ****p<0.0001. f. RT-PCR analysis of Chrebpb in the AclyBATKO mice 2 and 4 week of age. *p=0.0434, *p=0.0434, ****p<0.0001, ****p<0.0001. Panels A-F: grey bar (C), orange bar (AclyBATKO). Data are mean ± s.e.m. Group differences determined via one-tailed ANOVA with Tukey’s post hoc.

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