Extended Data Fig. 1: ACLY loss in Brown Fat Causes Tissue Whitening and Cold Intolerance in Male Mice. | Nature Metabolism

Extended Data Fig. 1: ACLY loss in Brown Fat Causes Tissue Whitening and Cold Intolerance in Male Mice.

From: Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress

Extended Data Fig. 1

a. Body weight of the AclyBATKO male mice. n=21 C, 16 KO. b. Adipose tissue weights of the AclyBATKO male mice. *p= 0.0246, *p= 0.0234. n=11 C, 8 KO. c. Lean tissue weights of the AclyBATKO male mice. n=11 C, 8 KO. d. ‘Survival curve’ for cold exposure experiment, where mice maintain body temperature above 30 °C, remain in the cold over the time course of experiment. n=C, 6 KO. e. Dorsal view representative infrared thermography image of heat signature of the iBAT from AclyBATKO mouse and littermate control. f. Body weights of the Acss2BATKO male mice. n=6 C, 6 KO. g. Adipose tissue weights of the Acss2BATKO male mice. n=6 C, 6 KO. h. Lean tissue weights of the Acss2BATKO male mice. n=6 C, 6 KO. i. ‘Survival curve’, how many mice remain in the cold over the time course of experiment. n=6 C, 6 KO. j. Acyl CoA levels measurements in the Acss2BATKO male mice BAT. **p= 0.0052, *p= 0.0170. n=9 C, 10 KO. Data are mean ± s.e.m. Statistical analysis unpaired two-tailed Student’s t-test.

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