Extended Data Fig. 5: Gut microbiome and Stroop Colour-Word Test and fMR metastability parameters associated with Gokushovirus. | Nature Metabolism

Extended Data Fig. 5: Gut microbiome and Stroop Colour-Word Test and fMR metastability parameters associated with Gokushovirus.

From: Microviridae bacteriophages influence behavioural hallmarks of food addiction via tryptophan and tyrosine signalling pathways

Extended Data Fig. 5

a) ANCOM-BC differential abundance (two-sided Z-test using the statistic W = log2Fold Change/standard error) plot at the family level for the Stroop Colour-Word Test – Word Colour (SCWT-WC) controlling for age, BMI, sex, and education years as covariates in men from the Aging Imageomics cohort (n = 475). Fold change associated with a unit change in the SCWT-WC score and log10 p values adjusted for multiple testing are plotted for each family. b, c) SHAP summary plot for the metastability in the resting-state networks associated with the iqlr-transformed Gokushovirus WZ-2015a levels identified through the Boruta algorithm after controlling for age, BMI, sex (only when applicable), and education level in the whole b) cohort and c) men, respectively. Each dot represents an individual sample. The X-axis represents the SHAP value: the impact of a specific resting-state network on the iqlr-transformed Gokushovirus WZ-2015a levels prediction of a specific individual. Features are sorted in decreasing order based on their overall importance for final prediction (average SHAP values shown in bold).

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