Extended Data Fig. 6: Metabolomics of nucleus accumbens in recipient mice according to the presence of Gokushovirus in donor’s microbiota.

a) Dot-plot of HMDB pathways enrichment in the NAc of recipient mice from metabolites significantly associated with the presence or absence (<10 counts) of Gokushovirus WZ-2015a from the human donor’s microbiota. b) Metabolite concept network depicting significant metabolites involved in the selected pathways. c) Volcano plot of metabolites identified in the DS of the recipient mice according to the presence or absence (<10 counts) of Gokushovirus WZ-2015a in the human donor’s microbiota using robust linear regression models (t-statistic based on M-estimation with Huber weighting solved using Iteratively Reweighted Least Squares) controlling for donors age, sex, BMI, and education years. Fold change and log10 p values adjusted for multiple comparisons are plotted. d) Dot-plot of KEGG enriched pathways in the DS of recipient mice from metabolites significantly associated with the presence or absence (<10 counts) of Gokushovirus WZ-2015a from the human donors microbiota. e) Metabolite concept network depicting significant metabolites involved in the selected pathways.