Extended Data Fig. 8: Microbiome families associated with the presence of food addiction and differential metabolites between the AA and control mice in the Nucleus accumbens.

Volcano plot of differential microbiome families associated with the presence of food addiction in a) all individuals (n = 147) and in b) women (n = 101) identified using ANCOM-BC (two-sided Z-test using the statistic W = log₂Fold Change/standard error) controlling for age, sex (only when individuals of both sexes were included in the analysis), and waist circumference. Fold changes and p values adjusted for multiple testing are plotted. c) Dot plot of significant (q-values < 0.1) over-represented (one-sided hypergeometric test) HMDB pathways identified from significantly differential metabolites between the AA and control mice in the NAc. d) Dot plot of KEGG module-based pathway over-representation analysis (one-sided hypergeometric test) based on the molecular function significantly associated with the iqlr-transformed Gokushovirus WZ-2015a levels identified using fastANCOM (padj<0.05). e) Metabolite concept network depicting significant metabolites involved in the selected pathways.