Extended Data Fig. 1: Expression profiles of the central clock genes under different experimental conditions. | Nature Metabolism

Extended Data Fig. 1: Expression profiles of the central clock genes under different experimental conditions.

From: The hepatic clock synergizes with HIF-1α to regulate nucleotide availability during liver damage repair

Extended Data Fig. 1

a, qRT-PCR showing expression of Cry1, Per2, and Dbp in C57BL/6 J mouse livers at the indicated time points after PH. b. Heatmap showing differential expression of genes related to the circadian clock and cell cycle during liver regeneration. Original data were derived from GSE215216 dataset. c-e. The expression patterns of the core clock genes in the livers of WT and LBKO mice (c), or WT mice fed AL or DRF (d,e), determined by qRT-PCR. For a,c-e, n = 3 mice per group. Data are mean ± s.e.m. P-values were calculated using two-way ANOVA with Sidak’s test (a). Rhythmicity analysis was performed using JTK_CYCLE as shown in Supplementary Table 1.

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