Extended Data Fig. 9: Comparative analysis of lipid and metabolite distribution in WT, 5xFAD, and Gaa-/- mouse brains.
From: AI-driven framework to map the brain metabolome in three dimensions
2D slice and 3D rendered views showing the distribution of specific lipids (LPE 22:4, PE 38:5, LPE 20:0, PE 38:4) and metabolites (ADP) across different mouse models: WT, 5xFAD (Alzheimer’s disease model), and Gaa-/-. The left panel compares WT and 5xFAD brains, while the right panel compares WT and Gaa-/- brains. The color scales indicate the relative intensity of the lipid/metabolite signals, illustrating differences in spatial distribution between the genotypes. These comparisons highlight alterations in brain metabolism and lipid composition associated with Alzheimer’s disease and GAA deficiency.
