Extended Data Fig. 8: Liraglutide augments PVNGLP-1R→DVC synaptic release in HFD-fed mice.
From: State-dependent central synaptic regulation by GLP-1 is essential for energy homeostasis
a. Representative traces of AMPAR-oEPSCs and NMDAR oEPSCs in HFD-fed mice with or without i.p. injection of 400 µg/kg liraglutide. b. Pooled data of NMDAR-oEPSCs (two-tailed t-test, t (43) = 2.561, p = 0.0153; HFD n = 18 cells/3 mice, Liraglutide n = 25 cells/3 mice). c. AMPAR/NMDAR oEPSCs ratio (two-tailed t-test, t(43) = 1.391, p = 0.1718; HFD n = 18 cells/3 mice, Liraglutide n = 18 cells/3 mice). Data are presented as mean ± SEM. ∗p < 0.05.
