Extended Data Fig. 7: Tau and glycogen interaction in iPSC-derived tauopathy neurons. | Nature Metabolism

Extended Data Fig. 7: Tau and glycogen interaction in iPSC-derived tauopathy neurons.

From: Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction

Extended Data Fig. 7

a, c, Co-localization study between tau and glycogenin 1 and across the line intensity plot for tauwt neurons. b, d, Co-localization study between tau and glycogenin 1 and across the line intensity plot for tauR406W neurons. e, Western blot of elute sediment from glycogen co-sedimentation assay with either tauWT or tauP301S using anti tau antibody showed tau sedimented with glycogen f, Western blot of elute sediment from glycogen co-sedimentation assay with BSA showed BSA did not sediment with glycogen. Co-sedimentation assay was repeated 3 times with similar results.

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