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Achter et al. established a protocol for quantitative proteomic profiling of formalin-fixed, paraffin-embedded human cardiac tissues, benchmarked against fresh-frozen samples. They applied it to stratify patients with arrhythmogenic cardiomyopathy and performed deep proteomic analysis of the human sinoatrial node.
Guo, Zhao and colleagues use high-resolution 7 T MRI to measure the pulsatility of cerebral small vessels and uncover age-related differences in vascular dynamics, which offer new insights into mechanisms of brain aging and vascular risks.
Chen, Yang et al. present DreAM, the drug-elicitable alternative splicing module, which is responsive to risdiplam, to inducibly regulate adeno-associated virus vector-mediated transgene expression. Proof-of-concept applications in cardiomyocytes revealed its potential for future clinical use in improving cardiac recovery after myocardial infarction.
Ling, Liu and colleagues introduce MSR, a multiscale recursive algorithm that enhances cardiac microscopy for precise cardiovascular signal extraction, and validate the approach in vitro and in vivo.
Wong et al. identify Slc6a2 as a marker of pulmonary venous endothelial cells and demonstrate that these cells differentiate into capillary endothelial cells during vascular regeneration after lung injury.
Porta-Sanchez et al. developed a pig model for Timothy syndrome (TS), which mirrors the severe heart condition seen in children with TS and also uncovers novel triggers of these life-threatening cardiac arrhythmias, illustrating the suitability of the new TS animal model for exploring new therapies.
Singh et al. developed a soft robotic model that can mimic the right ventricular motion and hemodynamics in healthy and pathological conditions and can be used as an in vitro simulator for tricuspid valve repair and replacement.
Warthi et al. generated an alpha 8 integrin-cre driver that enables gene targeting preferentially in vascular smooth muscle cells (SMCs) and showed in a proof-of-principle study, that using the Itga8-CreERT2 knock-in mouse for selective ablation of the Srf gene caused vascular defects but not a lethal visceral myopathy observed in an SMC-specific Myh11-CreERT2-driven Srf loss.
Despite an emerging role for cerebrovascular endothelial cells in a range of neurological pathologies, AAV vector development to date has focused on tools designed to target neurons or astrocytes. Here, Krolak et al. describe a specific variant of AAV (AAV-BI30), with high specificity and efficacy for transduction of endothelial cells across the central nervous system.
