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Volume 2 Issue 6, June 2024

High-throughput microfluidic 3D cell culture systems can be designed with different biological complexity, cell sources and cell configurations to model aspects of human tissues and organs. Such microfluidic systems can thereby serve as non-clinical testing tools for drug development. See Jihoon Ko et al.

Cover design: Simon Bradbrook

Editorial

  • Global health-related research and development continues to uphold colonialist structures, concentrating knowledge generation and innovation to high-income countries, thereby hindering global health equity. Therefore, in addition to engineering new technologies, bioengineers will need to try to engineer equitable relationships.

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Research Highlights

  • An article in Nature Materials reports a new ultrasoft and conformal liquid bioelectronic material for injectable and retrievable biosensing.

    • Sadra Bakhshandeh
    Research Highlight
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Reviews

  • Microfluidic 3D cell culture platforms may serve as tools for the modelling of human tissues. This Review discusses the design, standardization and automation of such systems for non-clinical drug evaluation and investigation of disease.

    • Jihoon Ko
    • Dohyun Park
    • Noo Li Jeon
    Review Article
  • Small-scale wireless soft robotic devices are promising tools for various medical applications. This Review outlines safety, navigation and functionality challenges, as well as the ethical and regulatory considerations that remain to be addressed for their clinical translation.

    • Tianlu Wang
    • Yingdan Wu
    • Metin Sitti
    Review Article
  • Ultrasound is an emerging tool for tissue engineering with the distinct advantages of cytocompatibility and deep tissue penetration. This Review discusses the integration of ultrasound for cellular assembly and tissue maturation with tissue-engineering techniques to advance regenerative medicine.

    • Kai Melde
    • Athanasios G. Athanassiadis
    • Peer Fischer
    Review Article
  • The application of nanoscale drug delivery systems by subcutaneous (SC) administration may circumvent disadvantages of other injections routes, such as intramuscular and intravenous administration. This Review discusses the design and clinical translation of nanoscale drug delivery systems for SC administration for the treatment of various conditions.

    • Lorenzo Tomasini
    • Marianne Ferrere
    • Julien Nicolas
    Review Article
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