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The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocampus to enable cross-species and functional interpretation.
Intracranial stimulation maps human brain causal connectivity, uncovering distinct pathways. The authors show that thalamic pulses uniquely evoke delayed theta oscillations, offering new insights into the brain’s functional architecture.
Dissecting the adaptive exercise response of the neurogenic stem-cell niche in the dentate gyrus by single-nucleus RNA sequencing reveals the molecular mediators that underlie exercise’s protective effects in Alzheimer’s disease.
Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.
This study maps the single-axon projections of 7,180 hypothalamic peptidergic neurons in male mice and uncovers extensive collateralization, topographic target innervation and modular intra-hypothalamic organization.
Multimodal transcriptomics unveil the molecular dynamics of neural stem cells and their surrounding niche in the aging mouse hippocampus and provide a resource to understand age-related molecular changes.
