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The RUNX transcription factors seem to have dichotomous roles in cancer, sometimes being oncogenic and sometimes acting as tumour suppressors. This Review discusses the many roles of the RUNX family in cancer biology.
Genome sequencing of therapy-related acute myeloid leukaemia (t-AML) has revealed that these malignancies do not have more mutations thande novo AML, and that TP53mutations, which are common in t-AML, are likely to be present before treatment with chemotherapy and expand following treatment.
