Articles in 2009

Tuberous sclerosis complex and von Hippel–Lindau disease are distinct autosomal dominant tumor suppressor syndromes that are characterized by solid and cystic renal lesions. The products of the affected genes are linked in an intricate pathway that regulates cell growth, proliferation, and vascular supply. This Review examines the phenotypic overlap between the diseases in the context of their pathophysiologic similarities, outlines the optimal management of both conditions, and highlights promising future pharmacologic interventions.

Skin disorders are very common in patients with chronic kidney disease and can seriously affect their mental and physical health. Although the majority of the disorders are relatively benign, some can cause serious morbidity and mortality. Early recognition of these severe skin disorders and prompt initiation of treatment can dramatically alter their course and even save a patient's life. This Review discusses characteristics, pathophysiology and treatment of uremic pruritus, calcific uremic arteriolopathy and nephrogenic systemic fibrosis, and briefly describes acquired perforating dermatosis (Kyrle disease) and porphyria cutanea tarda.