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Showing 1–50 of 2627 results
  • Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.

    • Nitsan Goldstein
    • Amadeus Maes
    • J. Nicholas Betley
    ResearchOpen Access
    Nature
    P: 1-9
  • Using a new analytical method for tracking gamma band events in mouse visual cortex, flexible encoding of visual information according to behavioural context is shown.

    • Quentin Perrenoud
    • Antonio H. de O. Fonseca
    • Jessica A. Cardin
    ResearchOpen Access
    Nature
    P: 1-8
  • The neural dynamics that optimize coordination of sensorimotor behaviour are not fully understood. Here authors show that the cerebellum receives a copy of the motor commands from the cerebrum during movement preparation, likely to generate motor predictions. During the execution, the cerebellum sends feedback to correct the motor cortical activity.

    • Vincenzo Romano
    • Matthijs van Driessche
    • Chris I. De Zeeuw
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • Reliable measuring the voltage dynamics of individual neurons in the intact brain is significantly challenging. Here authors developed an all-optical method combining two-photon voltage imaging and optogenetics to measure and induce synaptic plasticity in vivo, revealing LTP of inhibition in cerebellar circuits and providing a blueprint to link synaptic changes to learning.

    • Jacques Carolan
    • Michelle A. Land
    • Michael Häusser
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • Across species, how aging leads to progressive spatial memory decline is not fully understood. This study reports dysfunctional spatial coding by aged entorhinal grid cells and networks related to impaired spatial memory and identifies implicated neuronal gene expression changes.

    • Charlotte S. Herber
    • Karishma J. B. Pratt
    • Lisa M. Giocomo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-27
  • The roles of distinct dopaminergic neuron subpopulations and the circuit projections driving their activity during threat behaviors remain incompletely understood. Here, the authors demonstrate that substantia nigra pars lateralis dopamine neurons receive selective, robust excitation from auditory and temporal association cortices, which, combined with rapid action potential firing, contributes to auditory threat conditioning.

    • Lorenzo Sansalone
    • Emily L. Twedell
    • Zayd M. Khaliq
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • Separating firing rate from spiking irregularity is a key challenge in analyzing neural activity. Here, the authors present a mathematical model and inference method that capture diverse spike patterns across neurons, cortical areas, and cognitive states.

    • Cina Aghamohammadi
    • Chandramouli Chandrasekaran
    • Tatiana A. Engel
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • Cortical networks switch from asynchronous firing to sudden synchronized population events. Here, the authors show that differential excitatory short-term synaptic plasticity onto either excitatory or inhibitory targets establishes and shapes the dynamics of these population events.

    • Jeffrey B. Dunworth
    • Yunlong Xu
    • Brent Doiron
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • Xu et al. reveal that a bottom-up neural circuit from the medial septum to the subfornical organ prevents overhydration in mice by integrating oral and gastrointestinal signals before osmolality changes, demonstrating precise drinking control mechanisms.

    • Lingyu Xu
    • Yuhao Sun
    • Zhong Chen
    Research
    Nature Neuroscience
    P: 1-12
  • Key neurons in the orbitofrontal cortex form memories for best action strategies when mice seek rewards. Here, the authors show that these neurons have more mature dendritic spines than neighboring cells, this maturation requiring concurrent plasticity in the amygdala.

    • Sophie T. Yount
    • Dan C. Li
    • Shannon L. Gourley
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • Functional roles of the parvicellular part of the ventral posteromedial nucleus/gustatory thalamus are not fully understood. Here authors found that gustatory thalamus mediates aversive behaviors and responds to noxious stimuli and fear memory. Gustatory thalamus receives input from the parabrachial nucleus and innervates neurons in the insular cortex and rostral lateral amygdala.

    • Feng Cao
    • Sekun Park
    • Richard D. Palmiter
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • This PrimeView accompanies the Primer on Opioid use disorder by John Strang, Nora Volkow and colleagues, and summarizes the epidemiology, mechanisms, diagnosis and treatment of this disorder.

    Reviews
    Nature Reviews Disease Primers
    Volume: 6, P: 1
  • How the brain combines sensory with non-sensory information is unknown. Here, the authors find that sensory input from the thalamus to the apical dendrites of the main cortical output neurons enables the first stage of this combination process.

    • Arco Bast
    • Jason M. Guest
    • Marcel Oberlaender
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • Structural and functional understanding of the afferent inputs to histaminergic neurons remains incomplete and lacks systematic characterization. Herein, the authors establish a comprehensive and precise whole-brain atlas of long-range inputs to mouse histaminergic neurons and investigate the representative upstream histaminergic neural circuits in regulating the sleep-wake cycle.

    • Wenkai Lin
    • Xinyan Zhu
    • Zhong Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • Tree shrews show a primate-like hierarchical organization in their visual pathway and object decoding accuracy, along with strongly face-selective cells, demonstrating how core computational principles of visual form processing found in primates are conserved yet compressed.

    • Frank F. Lanfranchi
    • Joseph Wekselblatt
    • Doris Y. Tsao
    ResearchOpen Access
    Nature
    P: 1-11
  • Neural mechanisms underlying state-dependent flexible selection are not fully understood. Here authors show that NPY homologues in Drosophila larva differentially modulate reciprocally connected inhibitory neurons to bias non-feeding decisions, favoring escape-type actions (Head Cast), over protective-type actions (Hunch), in response to a mechanical cue.

    • Eloïse de Tredern
    • Dylan Manceau
    • Tihana Jovanic
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-24
  • The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases.

    • Mark A. Anderson
    • Jordan W. Squair
    • Grégoire Courtine
    Reviews
    Nature Neuroscience
    Volume: 25, P: 1584-1596
  • The dorsal peduncular area of the mouse brain functions as a network hub that integrates diverse cortical and thalamic inputs to regulate neuroendocrine and autonomic responses.

    • Houri Hintiryan
    • Muye Zhu
    • Hong-Wei Dong
    ResearchOpen Access
    Nature
    P: 1-15
  • How the interplay between internal and external network drives shapes the representation of the world is not fully understood. The authors show that internal generative network dynamics support non-local theta sequence coding, representational updating and flickering during navigation.

    • Yuchen Zhou
    • Jeremie Sibille
    • George Dragoi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21
  • Beck et al. develop a model where striosomes create a flexible “decision-space” that adapts to environmental context and internal state. It explains how we make choices and why decision-making varies between people, and in neuropsychiatric disorders.

    • Dirk W. Beck
    • Cory N. Heaton
    • Alexander Friedman
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-30
  • Our basic understanding of neuromodulation in the claustrum remains limited. Here Madden et al., identify a key mechanism by which serotonin and the psychedelic psilocybin modulate cortical signalling through the claustrum, a brain region involved in regulating cognition and brain network states.

    • Maxwell B. Madden
    • Chloe Schaefgen
    • Brian N. Mathur
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • The authors enable recording of circuit-scale neuronal voltage dynamics at > 5 kHz sampling rate by using an acquisition pipeline for voltage imaging that assigns each region of interest to a single pixel in the detector, enabling optimally compressed acquisition of intensity traces.

    • Seonghoon Kim
    • Jongmin Yoon
    • Myunghwan Choi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9
  • Madruga and colleagues present an open-source, miniature 2-photon microscope that can fit on a mouse’s head. Using this system, the authors perform high-resolution brain activity measurements in fine neuronal structures, which they can achieve even in conditions where the mouse is freely-moving within its cage.

    • Blake A. Madruga
    • Conor C. Dorian
    • Peyman Golshani
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • The role of glutamate-driven inhibition in neural computations and animal behavior is not fully understood. This study reveals that group III metabotropic glutamate receptors (mGluRs) mediate inhibition in the habenula, shaping sensory processing and defensive behaviors, highlighting a key role for glutamate-driven inhibition in the brain.

    • Anna Maria Ostenrath
    • Nicholas Faturos
    • Emre Yaksi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • Single-cell transcriptomic analysis of mouse hypothalamus and behavioural experiments show that specific hypothalamic networks regulate conflicting feeding versus parenting behaviours of female mice.

    • Ivan C. Alcantara
    • Chia Li
    • Michael J. Krashes
    Research
    Nature
    Volume: 645, P: 981-990
  • Whether sequential or persistent hippocampal activity patterns support working memory is not fully understood. Here authors found that, irrespective of the firing patterns—sequential or persistent, neither of these subgroups of cells was found to store a memory. These findings suggest that hippocampal activity alone does not maintain working memory over longer periods.

    • Li Yuan
    • Jose F. Figueroa
    • Stefan Leutgeb
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • The neural circuits that transmit cool signals remain not fully understood. Here, authors identify a spinal circuit in mice that transmits cool sensations from the skin to the brain, revealing a dedicated neural pathway for detecting innocuous cool temperatures.

    • Hankyu Lee
    • Chia Chun Hor
    • Bo Duan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18