Nature Search

Natural history of NAFLD: knowns and unknowns

Although nonalcoholic fatty liver disease is the most prevalent liver disease worldwide, there is a paucity of good-quality data on its natural history and most studies to date have reported on retrospective data. Robust data are required to inform regulatory end points, trial design and models of care.

Emmanuel A. Tsochatzis
News & Views08 Dec 2021
Nature Reviews Gastroenterology & Hepatology

Volume: 19, P: 151-152
Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds)

Gabriel H. Travis
Miles B. Brennan
J. Gregor Sutcliffe
Research02 Mar 1989
Nature

Volume: 338, P: 70-73
Molecular basis for the activation of outer dynein arms in cilia

Issa et al. show that the ciliary small guanosine triphosphatase Arl3 displaces the inhibitory regulator Shulin/DNAAF9 from the outer dynein arm, leading to motor activation.

Karim Housseini B. Issa
Muyang Ren
Girish R. Mali
ResearchOpen Access29 Sept 2025
Nature Structural & Molecular Biology

P: 1-11
Inductive capacity of irradiated dermal papillae

LAMEES IBRAHIM
E. A. WRIGHT
Research24 Feb 1977
Nature

Volume: 265, P: 733-734
Drug development: Sprint finish

Biotechnology start-ups and pharmaceutical giants alike are charging ahead to develop therapies for the most serious form of non-alcoholic fatty liver disease.

Liam Drew
Comments & Opinion22 Nov 2017
Nature

Volume: 551, P: S86-S89
Clinical validation of an AI-based pathology tool for scoring of metabolic dysfunction-associated steatohepatitis

In a prospective, regulatory-grade study of assistance to pathologists in MASH histology scoring, AIM-MASH-assisted reads by expert MASH pathologists were superior to unassisted reads and decreased inter-reader variability.

Hanna Pulaski
Stephen A. Harrison
Katy E. Wack
ResearchOpen Access04 Nov 2024
Nature Medicine

Volume: 31, P: 315-322
Clinical trial design, biomarkers and end points in metabolic and alcohol-related liver disease

Metabolic and alcohol-related liver disease presents challenges in clinical trials due to complex pathophysiology. This Review discusses noninvasive imaging, serum biomarkers and adaptive designs as modalities to enhance patient-centric end points, aiming to refine diagnostics and improve drug development.

Luis Antonio Diaz
Maja Thiele
Rohit Loomba
Reviews26 Sept 2025
Nature Reviews Gastroenterology & Hepatology

P: 1-19
Local structural distortions drive magnetic molecular field in compositionally complex spinel oxide

Understanding how local distortions affect the functional properties of high entropy materials remains an open challenge. This work found element-specific distortions beyond nearest neighbors and a flexible cationic sublattice in spinel oxides, linking mean-field magnetism to bond lengths.

Rukma Nevgi
Subha Dey
Srimanta Middey
ResearchOpen Access31 Jul 2025
Nature Communications

Volume: 16, P: 1-11
Opportunities and challenges for monitoring terrestrial biodiversity in the robotics age

An expert-elicitation process identifies current methodological barriers for monitoring terrestrial biodiversity, and how technological and procedural development of robotic and autonomous systems may contribute to overcoming these challenges.

Stephen Pringle
Martin Dallimer
Zoe G. Davies
ResearchOpen Access22 May 2025
Nature Ecology & Evolution

Volume: 9, P: 1031-1042
A null mutation in the human peripherin/RDS gene in a family with autosomal dominant retinitis punctata albescens

Kazuto Kajiwara
Michael A. Sandberg
Thaddeus P. Dryja
Research01 Mar 1993
Nature Genetics

Volume: 3, P: 208-212
Control of Turnip and Cabbage Mildew (Erysiphe polygoni DC.) by Zinc

J. A. TOMLINSON
M. J. W. WEBB
Research10 May 1958
Nature

Volume: 181, P: 1352-1353
DNA Replication Sites within Nuclei of Mammalian Cells

JOEL A. HUBERMAN
ALICE TSAI
ROBERT A. DEICH
Research05 Jan 1973
Nature

Volume: 241, P: 32-36
Evidence for endothermic quasicrystalline–crystalline phase transitions in Al₆CuMg₄

M. K. Sanyal
V. C. Sahni
G. K. Dey
Research20 Aug 1987
Nature

Volume: 328, P: 704-706
Permeabilities of Precambrian Onverwacht Cherts and Other Low Permeability Rocks

S. K. SANYAL
K. A. KVENVOLDEN
S. S. MARSDEN JUN.
Research30 Jul 1971
Nature

Volume: 232, P: 325-327
Trial design in NASH—realities and challenges

The conclusions of clinical trials in patients with nonalcoholic steatohepatitis (NASH) can be influenced by the study design. A group of experts has published recommendations for the design of studies in NASH; these recommendations represent a step towards a standardized methodology for clinical trials in this setting.

Paul Angulo
News & Views05 Aug 2011
Nature Reviews Gastroenterology & Hepatology

Volume: 8, P: 424-425
Publisher Correction: Integrating liver endpoints in clinical trials of cardiovascular and kidney disease

Faiez Zannad
Arun J. Sanyal
Stephen A. Harrison
Amendments and Corrections12 Jun 2025
Nature Medicine

Volume: 31, P: 2818
Long-term liver outcomes after metabolic surgery in compensated cirrhosis due to metabolic dysfunction-associated steatohepatitis

In individuals with obesity and compensated metabolic dysfunction-associated steatohepatitis-related cirrhosis, metabolic surgery was associated with a lower risk of major adverse liver outcomes, compared with nonsurgical management.

Ali Aminian
Abdullah Aljabri
Steven E. Nissen
Research27 Jan 2025
Nature Medicine

Volume: 31, P: 988-995
A three-base-pair deletion in the peripherin–RDS gene in one form of retinitis pigmentosa

G. Jane Farrar
Paul Kenna
Peter Humphries
Research12 Dec 1991
Nature

Volume: 354, P: 478-480
Endocannabinoids acting at vascular CB₁ receptors mediate the vasodilated state in advanced liver cirrhosis

Sándor Bátkai
Zoltán Járai
George Kunos
Research01 Jul 2001
Nature Medicine

Volume: 7, P: 827-832
Cardiac and liver impairment on multiorgan MRI and risk of major adverse cardiovascular and liver events

In 28,841 individuals who underwent cardiac and liver MRI before being followed for a median of 4.3 years, detection of both liver and cardiac impairment by MRI was associated with cardiovascular- and liver-related hospitalization.

Edward Jackson
Andrea Dennis
Amitava Banerjee
ResearchOpen Access07 May 2025
Nature Medicine

Volume: 31, P: 2289-2296
Positive Renal Response to Intravenous Acetazolamide in Patients with Carbonic Anhydrase II Deficiency

William S Sly
Michael P Whyte
Vasantha Sundaram
Research01 Oct 1985
Pediatric Research

Volume: 19, P: 1033-1036
Diagnostic performance of circulating biomarkers for non-alcoholic steatohepatitis

The NIMBLE biomarker qualification project evaluated the diagnostic performance of five blood-based biomarkers in a cohort of individuals with non-alcoholic fatty liver disease and showed good discriminative performance over commonly used laboratory tests in detecting various stages of non-alcoholic steatohepatitis progression.

Arun J. Sanyal
Sudha S. Shankar
Roberto A. Calle
ResearchOpen Access07 Sept 2023
Nature Medicine

Volume: 29, P: 2656-2664
Tropifexor for nonalcoholic steatohepatitis: an adaptive, randomized, placebo-controlled phase 2a/b trial

The FLIGHT-FXR trial, testing farnesoid X receptor agonist tropifexor in nonalcoholic steatohepatitis, demonstrated sustained decreases in alanine aminotransferase levels and hepatic fat fraction, but not aspartate aminotransferase, with dose-dependent pruritus being the most common adverse event.

Arun J. Sanyal
Patricia Lopez
Clifford A. Brass
ResearchOpen Access16 Feb 2023
Nature Medicine

Volume: 29, P: 392-400
Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila melanogaster CNS

The Toll receptor superfamily has a role in innate immunity that arose early in evolution. Here the authors show that in fruit flies, Toll-6 and Toll-7 function in the CNS as receptors for the fly neurotrophins DNT1 and DNT2.

Graham McIlroy
Istvan Foldi
Alicia Hidalgo
Research28 Jul 2013
Nature Neuroscience

Volume: 16, P: 1248-1256
Helenius et al. reply

Jonne Helenius
Davis T. W. Ng
Markus Aebi
Research31 Jul 2008
Nature

Volume: 454, P: E4-E5
A New Autotrophic Bacterium which Oxidises Ammonia directly to Nitrate and Decomposes Petroleum

C. B. LIPMAN
L. GREENBERG
Research06 Feb 1932
Nature

Volume: 129, P: 204-205
Enzyme-Substrate Complex Formation: a First Stage in Ribonuclease Activity

ANWAR A. HAKIM
Research08 Dec 1956
Nature

Volume: 178, P: 1293-1295
Paramagnetic shift probes in high-resolution solid-state NMR

A. K. Cheetham
C. M. Dobson
R. J. B. Jakeman
Research20 Aug 1987
Nature

Volume: 328, P: 706-707
Inhibition of Ascorbic Acid Oxidase by Thiourea

A. M. MAYER
Research21 Dec 1957
Nature

Volume: 180, P: 1417-1418
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation

A multiancestry genome-wide association study of chronic alanine aminotransferase elevation identifies candidate risk loci for nonalcoholic fatty liver disease, with replication in external cohorts defined by histology or imaging.

Marijana Vujkovic
Shweta Ramdas
Kyong-Mi Chang
Research02 Jun 2022
Nature Genetics

Volume: 54, P: 761-771
Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria

In bacteria, a newly identified endonuclease activated by ribosome collisions truncates mRNA to trigger rescue of stalled ribosomes.

Kazuki Saito
Hanna Kratzat
Allen R. Buskirk
Research09 Mar 2022
Nature

Volume: 603, P: 503-508
Pharmacological agents for NASH

Optimal management of NASH is required because the condition can progress to cirrhosis and end-stage liver failure. Once first-line therapy with diet and lifestyle changes has failed, pharmacological intervention is indicated. This Review discusses the available evidence from clinical trials on pharmacological agents for NASH.

Vlad Ratziu
Reviews15 Oct 2013
Nature Reviews Gastroenterology & Hepatology

Volume: 10, P: 676-685
A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Here the authors develop a ferritin-based protein nanoparticle vaccine candidate for SARS-CoV-2, and show induction of neutralizing antibodies to variants of concern, including Omicron BQ.1, in non-human primates after initial immunization and a booster dose.

Payton A.-B. Weidenbacher
Mrinmoy Sanyal
Peter S. Kim
ResearchOpen Access17 Apr 2023
Nature Communications

Volume: 14, P: 1-13
An integrated encyclopedia of DNA elements in the human genome

This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

Ian Dunham
Anshul Kundaje
Ewan Birney
ResearchOpen Access05 Sept 2012
Nature

Volume: 489, P: 57-74
Effects of α-tocopherol and β-carotene supplementation on liver cancer incidence and chronic liver disease mortality in the ATBC study

G Y Lai
S J Weinstein
N D Freedman
ResearchOpen Access14 Oct 2014
British Journal of Cancer

Volume: 111, P: 2220-2223
Tapasin assembly surveillance by the RNF185/Membralin ubiquitin ligase complex regulates MHC-I surface expression

Loading of antigenic peptides onto MHC-I is essential for adaptive immunity and requires the protein Tapasin. Here, the authors demonstrate that Tapasin levels are controlled by the RNF185/MBRL ERAD complex and that this process regulates MHC-I surface expression.

Michael L. van de Weijer
Krishna Samanta
Pedro Carvalho
ResearchOpen Access01 Oct 2024
Nature Communications

Volume: 15, P: 1-14
The accessible chromatin landscape of the human genome

An extensive map of human DNase I hypersensitive sites, markers of regulatory DNA, in 125 diverse cell and tissue types is described; integration of this information with other ENCODE-generated data sets identifies new relationships between chromatin accessibility, transcription, DNA methylation and regulatory factor occupancy patterns.

Robert E. Thurman
Eric Rynes
John A. Stamatoyannopoulos
ResearchOpen Access05 Sept 2012
Nature

Volume: 489, P: 75-82
Is it necessary to endoscopically screen all patients with hepatitis C and advanced fibrosis for esophageal varices?

Juan-Carlos Garcia-Pagan
Comments & Opinion15 May 2007
Nature Clinical Practice Gastroenterology & Hepatology

Volume: 4, P: 370-371
Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells

Reduced fitness of the tumor microenvironment is mediated by a long non-coding RNA expressed in tumors.

Esha Madan
António M. Palma
Rajan Gogna
Research09 Dec 2024
Nature Biotechnology

P: 1-15
Investigating hepatic fibrosis heterogeneity by three-dimensional imaging in metabolic dysfunction-associated steatotic liver disease

Buket Yigit
Ekin Ozgonul
Müjdat Zeybel
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Treatment strategies in nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease is an increasingly recognized health problem. Its presentation ranges from simple steatosis to its inflammatory representation of nonalcoholic steatohepatitis. This Review considers various modalities that have been tried for nonalcoholic fatty liver disease, such as weight loss and/or exercise, thiazolidinediones, metformin, lipid-lowering agents and antioxidants, as well as considering treatments that are on the horizon.

Herbert Tilg
Arthur Kaser
Reviews01 Mar 2005
Nature Clinical Practice Gastroenterology & Hepatology

Volume: 2, P: 148-155
Identification of antiviral RNAi regulators, ILF3/DHX9, recruit at ZIKV stem loop B to protect against ZIKV induced microcephaly

In this study, the authors perform an interactome study of Zika virus (ZIKV) 5’UTR stem-loop B region and identify two host factors, interleukin enhancer binding factor 3 (ILF3) and DEAH-box helicase 9 (DHX9), that positively regulate antiviral RNAi to inhibit virus replication and ZIKV-induced microcephaly in vivo.

Zhiwei Lei
Yu Gu
Xin Chen
ResearchOpen Access26 Feb 2025
Nature Communications

Volume: 16, P: 1-18
ENCODE explained

The Encyclopedia of DNA Elements (ENCODE) project dishes up a hearty banquet of data that illuminate the roles of the functional elements of the human genome. Here, six scientists describe the project and discuss how the data are influencing research directions across many fields. See Articles p.57, p.75, p.83, p.91, p.101 & Letter p.109

Joseph R. Ecker
Wendy A. Bickmore
Eran Segal
News & Views05 Sept 2012
Nature

Volume: 489, P: 52-54
Translational roles of the C75 2′OH in an in vitro tRNA transcript at the ribosomal A, P and E sites

Jinfan Wang
Anthony C. Forster
ResearchOpen Access27 Jul 2017
Scientific Reports

Volume: 7, P: 1-8
Morphine Withdrawal Syndrome Responses to Cholinergic Antagonists and to a Partial Cholinergic Agonist

C. PINSKY
R. C. A. FREDERICKSON
A. J. VAZQUEZ
Research02 Mar 1973
Nature

Volume: 242, P: 59-60
Comments on the “Isolation, Identification and Synthesis of a Specific-behaviour-inducing Brain Peptide”

A. GOLDSTEIN
Research02 Mar 1973
Nature

Volume: 242, P: 60-62
Reversible monolayer-to-crystalline phase transition in amphiphilic silsesquioxane at the air-water interface

R. Banerjee
M. K. Sanyal
M. Meron
ResearchOpen Access17 Feb 2015
Scientific Reports

Volume: 5, P: 1-8
Recipe for High Moment Materials with Rare-earth and 3d Transition Metal Composites

Carmine Autieri
P. Anil Kumar
Biplab Sanyal
ResearchOpen Access06 Jul 2016
Scientific Reports

Volume: 6, P: 1-9
Entropic control of particle motion using passive surface microstructures

A. D. Dinsmore
A. G. Yodh
D. J. Pine
Research19 Sept 1996
Nature

Volume: 383, P: 239-242
Postnatal development of the synaptic organisation of the lateral geniculate nucleus in the kitten with unilateral eyelid closure

D. A. WINFIELD
M. P. HEADON
T. P. S. POWELL
Research14 Oct 1976
Nature

Volume: 263, P: 591-594

Search

Filter By:

Search

Quick links