Nature Search

Crystallinity of covalent organic frameworks controls immune responses

Effects of biomaterials crystallinity on immune response is poorly understood. Here the authors show that the degree of crystallinity determines adjuvant-like effects of covalent organic framework (COF) biomaterial, with lower crystallinity correlating with better anti-tumour effects in multiple mouse tumour models.

Arezoo Esrafili
Abhirami Thumsi
Abhinav P. Acharya
ResearchOpen Access11 Nov 2024
Nature Communications

Volume: 15, P: 1-14
CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells

The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.

Hind Rafei
Rafet Basar
Katayoun Rezvani
ResearchOpen Access04 Jun 2025
Nature

Volume: 643, P: 1076-1086
Bacteria invade the brain following intracortical microelectrode implantation, inducing gut-brain axis disruption and contributing to reduced microelectrode performance

Brain-machine interfaces are hindered by neuroinflammation. Here, the authors found that bacterial sequences invade the brain post-microelectrode implantation. Antibiotic-treated mice showed reduced bacterial presence and altered neuroinflammatory profile, temporarily improving recording performance.

George F. Hoeferlin
Sarah E. Grabinski
Jeffrey R. Capadona
ResearchOpen Access20 Feb 2025
Nature Communications

Volume: 16, P: 1-27
Comparison of Bladder Carcinogens in the Urine of E-cigarette Users Versus Non E-cigarette Using Controls

Thomas W. Fuller
Abhinav P. Acharya
Tatum V. Tarin
ResearchOpen Access11 Jan 2018
Scientific Reports

Volume: 8, P: 1-6
Rescue of dendritic cells from glycolysis inhibition improves cancer immunotherapy in mice

While glycolysis inhibition impairs cancer cell tumourigenic capacities, it also affects immune cells anti-tumour activity. Here, the authors show that rescuing glycolytic inhibition of dendritic cells improves the efficacy of combining immunotherapy with glycolysis inhibition.

Sahil Inamdar
Abhirami P. Suresh
Abhinav P. Acharya
ResearchOpen Access02 Sept 2023
Nature Communications

Volume: 14, P: 1-12
Immunity without harm

Multilamellar lipid vesicles with crosslinked walls carrying protein antigens in the vesicle core and immunostimulatory drugs in the vesicle walls generate immune responses comparable to the strongest live vector vaccines.

Abhinav P. Acharya
Niren Murthy
News & Views21 Feb 2011
Nature Materials

Volume: 10, P: 166-168
Metabolic engineering of lactate dehydrogenase rescues mice from acidosis

Abhinav P. Acharya
Mohammad Rafi
Niren Murthy
ResearchOpen Access05 Jun 2014
Scientific Reports

Volume: 4, P: 1-5
Comprehensive proteomic analysis of the differential expression of 62 proteins following intracortical microelectrode implantation

Sydney S. Song
Lindsey N. Druschel
Jeffrey R. Capadona
ResearchOpen Access30 Jul 2024
Scientific Reports

Volume: 14, P: 1-20
Synthesis and characterization of CaSr-Metal Organic Frameworks for biodegradable orthopedic applications

Naomi Joseph
Harrison D. Lawson
Steven R. Little
ResearchOpen Access10 Sept 2019
Scientific Reports

Volume: 9, P: 1-11
TRI Microspheres prevent key signs of dry eye disease in a murine, inflammatory model

Michelle L. Ratay
Stephen C. Balmert
Steven R. Little
ResearchOpen Access13 Dec 2017
Scientific Reports

Volume: 7, P: 1-9

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