Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results
Advanced filters: Author: Ajay S. Thatte Clear advanced filters

  • A platform for mRNA lipid nanoparticle delivery to the placenta to treat pre-eclampsia is shown to improve fetal and maternal health in mice and has potential clinical applications in obstetric disorders and women’s health.

    • Kelsey L. Swingle
    • Alex G. Hamilton
    • Michael J. Mitchell
    Research
    Nature
    Volume: 637, P: 412-421

  • Successful gene delivery is predicated on the effective cellular uptake of encapsulated nucleic acid cargo. Now, a study identifies extracellular fluid viscosity as a key factor that governs gene delivery via non-viral and viral vectors across a range of cell types.

    • Ajay S. Thatte
    • Dongyoon Kim
    • Michael J. Mitchell
    News & Views
    Nature Chemical Engineering
    Volume: 1, P: 559-560

  • Immunotherapy represents an important advance in cancer treatment, yet faces challenges owing to lack of precise control, leading to systemic effects and suboptimal results for patients. This Review explores how responsive biomaterials can enhance cancer immunotherapies by responding to various internal and external stimuli to regulate the delivery and behaviour of therapeutic agents, thereby improving efficacy and reducing toxicity in treatment methods such as cancer vaccines, T cell-based therapies and sustained delivery systems.

    • Lulu Xue
    • Ajay S. Thatte
    • Michael J. Mitchell
    Reviews
    Nature Reviews Materials
    Volume: 9, P: 100-118