Nature Search

Use of cyclosporin A in allogeneic bone marrow transplantation in the rat

PETER J. TUTSCHKA
WILLIAM E. BESCHORNER
GEORGE W. SANTOS
Research01 Jul 1979
Nature

Volume: 280, P: 148-151
Tumour cells mimic erythroblasts to hijack iron from bone marrow macrophages

A preprint by Han et al. reports that tumour cells acquire iron in the bone marrow through phenotypic mimicry of erythroblasts, which promotes metastasis and leads to systemic anaemia.

Mehdi Chaib
James P. Allison
Research Highlights01 Jul 2025
Nature Reviews Immunology

Volume: 25, P: 557
A pilot feasibility randomised controlled trial of bone antiresorptive agents on bone turnover markers in critically ill women

Neil R. Orford
Allison Bone
Rinaldo Bellomo
ResearchOpen Access24 Jan 2024
Scientific Reports

Volume: 14, P: 1-10
Parathyroid hormone measurements not useful for the assessment of bone turnover

Susan J. Allison
Research Highlights01 Oct 2009
Nature Reviews Nephrology

Volume: 5, P: 550
Bone and the kidney: it's complex

Susan J. Allison
Editorial24 Oct 2013
Nature Reviews Nephrology

Volume: 9, P: 623
Discovery and development of a new oxazolidinone with reduced toxicity for the treatment of tuberculosis

MK-7762 is a new oxazolidinone antitubercular agent that is structurally similar to linezolid, and demonstrated in vivo efficacy, lesion penetration and limited toxicity compared to linezolid, indicating it could be used in broad tuberculosis regimens.

Brendan M. Crowley
Helena I. Boshoff
David B. Olsen
ResearchOpen Access13 Jan 2026
Nature Medicine

Volume: 32, P: 553-560
Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis

Hepatic bone morphogenetic protein 8b expression is shown to be induced in NASH to drive wound healing responses and NASH progression by promoting inflammatory pathways in hepatic stellate cells and, more broadly, in the liver parenchyma.

Michele Vacca
Jack Leslie
Antonio Vidal-Puig
Research08 Jun 2020
Nature Metabolism

Volume: 2, P: 514-531
Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming

Pulmonary type 2 inflammation is associated with type 2 innate lymphoid cells. Here the authors use the Collaborative Cross mouse panel to show that ILC2 abundance during type 2 lung inflammation is different across the panel and identify free-fatty acid receptor 3 (Ffar3) as a gene responsible and show cytokine and ILC2 functional changes.

Mark Rusznak
Shinji Toki
R. Stokes Peebles Jr
ResearchOpen Access03 Jan 2026
Nature Communications

Volume: 17, P: 1-23
Origin of Thy-1⁺ dendritic epidermal cells of adult mice from fetal thymic precursors

Wendy L. Havran
James P. Allison
Research01 Mar 1990
Nature

Volume: 344, P: 68-70
Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche

Boyd et al. monitored the effects of patient-derived acute myeloid leukaemia (AML) cells on human HSPCs in vivo and found that AML impairs bone marrow adipocyte differentiation, and this in turn impedes healthy endogenous haematopoiesis.

Allison L. Boyd
Jennifer C. Reid
Mickie Bhatia
Research16 Oct 2017
Nature Cell Biology

Volume: 19, P: 1336-1347
Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

Therapy resistant dormant myeloma cells contribute to disease relapse. Here, the authors use intravital microscopy to track the location of these cells and demonstrate that they hone to the endosteal niche within the bone.

Michelle A. Lawson
Michelle M. McDonald
Peter I. Croucher
ResearchOpen Access03 Dec 2015
Nature Communications

Volume: 6, P: 1-15
Menopause-induced 17β-estradiol and progesterone loss increases senescence markers, matrix disassembly and degeneration in mouse cartilage

Knee osteoarthritis has a sex-specific phenotype with post-menopausal persons experiencing the highest incidence. Here the authors investigate the underlying mechanisms in a mouse model of menopause and find that the loss of 17β-estradiol and progesterone enhanced susceptibility to senescence, extracellular matrix disassembly and cartilage degradation.

Gabrielle Gilmer
Hirotaka Iijima
Fabrisia Ambrosio
Research16 Jan 2025
Nature Aging

Volume: 5, P: 65-86
Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function

Bohlen and colleagues report that the E3 ubiquitin ligase CBL is necessary for the development, tolerance and activation of B cells in humans, unlike in mice where CBL deficiency results in loss of T cells.

Taja Vatovec
Anna-Lena Neehus
Jonathan Bohlen
ResearchOpen Access15 Jan 2026
Nature Immunology

Volume: 27, P: 308-322
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice

Chronic stress is a risk factor for depression, yet the mechanisms are unclear. Here, the authors show in mice that stress drives interferon-mediated neutrophil recruitment from the skull to the brain’s outer membranes, contributing to depressive behaviors.

Stacey L. Kigar
Mary-Ellen Lynall
Miles Herkenham
ResearchOpen Access01 Sept 2025
Nature Communications

Volume: 16, P: 1-19
Asbestos induces selective release of lysosomal enzymes from mononuclear phagocytes

PHILIP DAVIES
ANTHONY C. ALLISON
SUSAN WILLIAMS
Research04 Oct 1974
Nature

Volume: 251, P: 423-425
Bone loss with aging is independent of gut microbiome in mice

Xiaomeng You
Jing Yan
Julia F. Charles
ResearchOpen Access11 Nov 2024
Bone Research

Volume: 12, P: 1-14
Increased susceptibility to virus oncogenesis of congenitally thymus-deprived nude mice

A. C. ALLISON
J. N. MONGA
V. HAMMOND
Research20 Dec 1974
Nature

Volume: 252, P: 746-747
Effects of Antilymphocyte Serum on Induction of Tumours and Leukaemia by Murine Sarcoma Virus

LLOYD W. LAW
R. C. TING
A. C. ALLISON
Research09 Nov 1968
Nature

Volume: 220, P: 611-612
Induction of osteoblast apoptosis stimulates macrophage efferocytosis and paradoxical bone formation

Lena Batoon
Amy Jean Koh
Hernan Roca
ResearchOpen Access05 Aug 2024
Bone Research

Volume: 12, P: 1-14
Autoimmune diabetes as a consequence of locally produced interleukin-2

William R. Heath
Janette Allison
Jacques F. A. P. Miller
Research08 Oct 1992
Nature

Volume: 359, P: 547-549
Immunological Control of Polyoma Virus Oncogenesis in Mice

J M Gaugas
A C Allison
M S Hirsch
Research01 Jan 1973
British Journal of Cancer

Volume: 27, P: 10-17
Requirement of Thymus-dependent Lymphocytes for Potentiation by Adjuvants of Antibody Formation

A. C. ALLISON
A. J. S. DAVIES
Research01 Oct 1971
Nature

Volume: 233, P: 330-332
Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors

Wendy L. Havran
James P. Allison
Research29 Sept 1988
Nature

Volume: 335, P: 443-445
Prevention of diabetes in non-obese diabetic I-A^k transgenic mice

Robyn M. Slattery
Lars Kjer-Nielsen
Jacques F. A. P. Miller
Research21 Jun 1990
Nature

Volume: 345, P: 724-726
Real-world use of bone modifying agents in metastatic, castration-resistant prostate cancer

Aaron P. Mitchell
Akriti Mishra Meza
Michael J. Morris
Research07 Jul 2022
Prostate Cancer and Prostatic Diseases

Volume: 26, P: 126-132
Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection

During SARS-CoV-2 infection caspase-8 fuels harmful inflammation independent of apoptosis. Genetic loss of caspase-8 reduces cytokine levels, lowers viral load and mitigates disease severity, revealing non-apoptotic caspase-8 as a key driver of severe COVID-19.

Stefanie M. Bader
Lena Scherer
Marcel Doerflinger
ResearchOpen Access13 Nov 2025
Nature Communications

Volume: 16, P: 1-21
STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13

The transcription factor STAT3 regulates production of inflammatory cytokines by modulating NF-κB signalling. Here the authors show that STAT3 is a transcriptional repressor of the E2 ubiquitin-conjugating enzyme Ubc13, modulating NF-κB by regulating Ubc13 abundance.

Huiyuan Zhang
Hongbo Hu
Stephanie S. Watowich
Research15 Dec 2014
Nature Communications

Volume: 5, P: 1-10
Neonatally Induced Allograft Tolerance may be mediated by Serum-borne Factors

INGEGERD HELLSTRÖM
KARL ERIK HELLSTRÖM
ANTHONY C. ALLISON
Research05 Mar 1971
Nature

Volume: 230, P: 49-50
Efferocytosis by bone marrow mesenchymal stromal cells disrupts osteoblastic differentiation via mitochondrial remodeling

Emily R. Quarato
Noah A. Salama
Laura M. Calvi
ResearchOpen Access14 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-15
Vaccine Technology: Adjuvants for Increased Efficacy

Anthony C. Allison
Noelene E. Byars
Research01 Oct 1987
Bio/Technology

Volume: 5, P: 1041-1045
Aptamer-based multiplexed proteomic technology for biomarker discovery

Larry Gold
Deborah Ayers
Dom Zichi
ResearchOpen Access14 Jun 2010
Nature Precedings

P: 1
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Necroptosis is a regulated form of inflammatory cell death driven by activated MLKL. Here, the authors identify a mutation in the brace region that confers constitutive activation, leading to lethal inflammation in homozygous mutant mice and providing insight into human mutations in this region.

Joanne M. Hildebrand
Maria Kauppi
John Silke
ResearchOpen Access19 Jun 2020
Nature Communications

Volume: 11, P: 1-16
Acitretin mitigates uroporphyrin-induced bone defects in congenital erythropoietic porphyria models

Juliana Bragazzi Cunha
Jared S. Elenbaas
M. Bishr Omary
ResearchOpen Access05 May 2021
Scientific Reports

Volume: 11, P: 1-10
Correcting B₀ inhomogeneity-induced distortions in whole-body diffusion MRI of bone

Leonardino A. Digma
Christine H. Feng
Tyler M. Seibert
ResearchOpen Access07 Jan 2022
Scientific Reports

Volume: 12, P: 1-9
CCR5 maintains macrophages in the bone marrow and drives hematopoietic failure in a mouse model of severe aplastic anemia

Allison N. Seyfried
Amanda McCabe
Katherine C. MacNamara
Research20 Mar 2021
Leukemia

Volume: 35, P: 3139-3151
Clonal haematopoiesis and risk of chronic liver disease

A study shows that clonal haematopoiesis of indeterminate potential is associated with an increased risk of chronic liver disease specifically through the promotion of liver inflammation and injury.

Waihay J. Wong
Connor Emdin
Pradeep Natarajan
Research12 Apr 2023
Nature

Volume: 616, P: 747-754
Molecular damage associated with ageing drives inflammation in cardiovascular disease

In this Review, Ferrucci and colleagues propose that inflammation is a resilience mechanism that resolves molecular and cellular damage driven by environmental stressors. With ageing, however, this protective response can become dysregulated and maladaptive, promoting collateral changes central to the pathophysiology of cardiovascular disease.

Allison B. Herman
Julián Candia
Luigi Ferrucci
Reviews22 Jan 2026
Nature Reviews Cardiology

P: 1-14
Regulation of T-cell receptor γ-chain RNA expression in murine Thy-1⁺ dendritic epidermal cells

William A. Kuziel
Akira Takashima
Philip W. Tucker
Research16 Jul 1987
Nature

Volume: 328, P: 263-266
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Joshua S. Weinstock
Jayakrishnan Gopakumar
Siddhartha Jaiswal
Research12 Apr 2023
Nature

Volume: 616, P: 755-763
EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription

Chr3q26 rearrangements cause overexpression of EVI1 and associate with myeloid neoplasms, but the mechanism behind this association is unclear. Here, using a novel mouse model they show that EVI1 causes premalignant myeloid expansion with suppression of other lineages through upregulation of Spi1/PU.1.

Edward Ayoub
Michael P. Wilson
Archibald S. Perkins
ResearchOpen Access12 Oct 2018
Nature Communications

Volume: 9, P: 1-12
Cytolytic effects of the complement cleavage product, C3a

J Ferluga
H U Schorlemmer
A C Allison
Research01 Dec 1976
British Journal of Cancer

Volume: 34, P: 626-634
Effects of seven days’ fasting on physical performance and metabolic adaptation during exercise in humans

During starvation, muscle strength and endurance, are still critical for survival. Seven days of complete fasting did not reduce maximal strength in leg muscles, but maximal endurance capacity was decreased because carbohydrate oxidation was restrained.

Kristoffer J. Kolnes
Emelie T. F. Nilsen
Jørgen Jensen
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-14
3D imaging reveals changes in the neurovascular architecture of the murine calvarium with aging

Allison L. Horenberg
Yunke Ren
Warren L. Grayson
ResearchOpen Access21 Feb 2025
Bone Research

Volume: 13, P: 1-13
Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury

A potentially superior tissue regenerative strategy to stem cell transplantation is modulation of endogenous stem cells. Here the authors show fibrocartilage stem cells exist in the temporomandibular joint that contribute to cartilage regeneration and can be manipulated to enhance regeneration through canonical Wnt signalling.

Mildred C. Embree
Mo Chen
Jeremy J. Mao
ResearchOpen Access10 Oct 2016
Nature Communications

Volume: 7, P: 1-13
Neural xenografts contribute to long-term recovery in stroke via molecular graft-host crosstalk

In this study, Weber et al., investigate the long-term survival and integration of human stem cell-derived neural progenitors into the stroke-injured mouse brains. They report grafted cells integrate into host circuits and mediate repair through graft-host crosstalk via neurexin, neuregulin, neural cell adhesion molecules, and SLIT signalling pathways.

Rebecca Z. Weber
Beatriz Achón Buil
Ruslan Rust
ResearchOpen Access16 Sept 2025
Nature Communications

Volume: 16, P: 1-23
Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy

The response rate of relapsed/refractory acute myeloid leukemia patients to PD-1 checkpoint blockade is low and unpredictable. Authors here show by single cell RNA sequencing, T cell receptor profiling and genomic analysis that the phenotypes and repertoire of CD8 + T cells and loss of chromosome 7/7q are important determinants of response.

Hussein A. Abbas
Dapeng Hao
Andrew Futreal
ResearchOpen Access18 Oct 2021
Nature Communications

Volume: 12, P: 1-13
Spatial transcriptomics of the developing mouse brain immune landscape reveals effects of maternal immune activation and microbiome depletion

Kukreja, Jeon et al. leverage spatial transcriptomics to map immune gene expression in the developing mouse brain, identifying key sex-specific changes in the context of maternal gut−immune perturbations.

Bharti Kukreja
Shin Jeon
Brian T. Kalish
Research06 Jan 2026
Nature Neuroscience

P: 1-14
A consensus guide to preclinical indirect calorimetry experiments

The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

Alexander S. Banks
David B. Allison
Juleen R. Zierath
Reviews24 Sept 2025
Nature Metabolism

Volume: 7, P: 1765-1780
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Wei Jiao
Gurnit Atwal
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-12
PPP2R1A mutations portend improved survival after cancer immunotherapy

Inactivating PPP2R1A mutations correlate with better survival after immune checkpoint blockade in patients with ovarian clear cell carcinoma, suggesting that targeting the phosphatase 2A (PP2A) pathway may represent an effective startegy for improving responses to immunotherapy.

Yibo Dai
Anne Knisely
Amir A. Jazaeri
ResearchOpen Access02 Jul 2025
Nature

Volume: 644, P: 537-546

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