Nature Search

Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking

Timothy M. Block
Xuanyong Lu
Raymond A. Dwek
Research01 May 1998
Nature Medicine

Volume: 4, P: 610-614
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Value addition to dietetic frozen yoghurt through use of fruit peel solids

Shaikh Adil
A. H. Jana
Bhargav Rajani
ResearchOpen Access13 Aug 2024
Scientific Reports

Volume: 14, P: 1-9
Fusarium Wilt of Guava (Psidium guyava L.) in Uttar Pradesh, India

N. PRASAD
P. R. MEHTA
S. B. LAL
Research03 May 1952
Nature

Volume: 169, P: 753
Finite element study of the efficacy of three different loops for bodily protraction of the mandibular molar

Aditi Mehta
Alap Shah
Anand Marya
ResearchOpen Access22 Apr 2025
Scientific Reports

Volume: 15, P: 1-7
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

The molecular and cellular causes of glaucoma are not well understood. Here, the authors integrate GWAS with genetic regulation and single cell expression from multiple eye tissues to identify genes and key cell types that affect glaucoma pathogenesis.

Andrew R. Hamel
Wenjun Yan
Ayellet V. Segrè
ResearchOpen Access09 Jan 2024
Nature Communications

Volume: 15, P: 1-25
Does earning money empower women? Evidence from India

Arohi Anand
Animesh Karn
Naboshree Bhattacharya
ResearchOpen Access08 Mar 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-17
QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration

Here, the authors perform genome-wide mapping of DNA methylation and expression quantitative trait loci, revealing associations among genotype, epigenome and transcriptome, uncovering genes and gene-environment interactions contributing to age-related macular degeneration (AMD).

Jayshree Advani
Puja A. Mehta
Anand Swaroop
ResearchOpen Access04 Mar 2024
Nature Communications

Volume: 15, P: 1-20
The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants

Familial myeloid malignancies have recently been classified as separate disease entities. Here, using whole-exome sequencing of affected pedigrees - the authors highlight genetic variants associated with these conditions.

Ana Rio-Machin
Tom Vulliamy
Inderjeet Dokal
ResearchOpen Access25 Feb 2020
Nature Communications

Volume: 11, P: 1-12
Identification of essential genes for cancer immunotherapy

The authors describe a two-cell-type CRISPR screen to identify tumour-intrinsic genes that regulate the sensitivity of cancer cells to effector T cell function.

Shashank J. Patel
Neville E. Sanjana
Nicholas P. Restifo
Research07 Aug 2017
Nature

Volume: 548, P: 537-542
Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Research06 May 2020
Nature

Volume: 583, P: 90-95
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
PEPlife: A Repository of the Half-life of Peptides

Deepika Mathur
Satya Prakash
Gajendra P. S. Raghava
ResearchOpen Access07 Nov 2016
Scientific Reports

Volume: 6, P: 1-7
Prediction of hemolytic peptides and their hemolytic concentration

Developed models predict and quantify hemolytic activity of peptides. A hybrid model achieves AUROC of 0.921, regression models show R = 0.739. Implemented in HemoPI2, enabling peptide design with desired HC50 values.

Anand Singh Rathore
Nishant Kumar
Gajendra P. S. Raghava
ResearchOpen Access04 Feb 2025
Communications Biology

Volume: 8, P: 1-14
Intrinsic hepatocyte dedifferentiation is accompanied by upregulation of mesenchymal markers, protein sialylation and core alpha 1,6 linked fucosylation

Anand Mehta
Mary Ann Comunale
Michael J. Bouchard
ResearchOpen Access22 Jun 2016
Scientific Reports

Volume: 6, P: 1-14
CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Chromodomain Helicase DNA-binding (CHD) proteins have been implicated in neurodevelopmental processes. Here, the authors identify missense variants in CHD3 that disturb its chromatin remodeling activities and cause a neurodevelopmental disorder with macrocephaly and speech and language impairment.

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
ResearchOpen Access05 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing

Tumor–normal paired DNA samples from a breast cancer cell line and a matched lymphoblastoid cell line enable calibration of clinical sequencing pipelines and benchmarking ‘tumor-only’ or ‘matched tumor–normal’ analyses.

Li Tai Fang
Bin Zhu
Yuanting Zheng
Research09 Sept 2021
Nature Biotechnology

Volume: 39, P: 1151-1160
Prevalence and architecture of de novo mutations in developmental disorders

Whole-exome analysis of individuals with developmental disorders shows that de novo mutations can equally cause loss or altered protein function, but that most mutations causing altered protein function have not yet been described.

Jeremy F. McRae
Stephen Clayton
Matthew E. Hurles
Research25 Jan 2017
Nature

Volume: 542, P: 433-438
CRISPR/Cas9-engineering of Kell null erythrocytes to unveil host targeted irresistible antimalarial

This study highlights Kell, a zinc endopeptidase, as a key host-factor in P. falciparum invasion and demonstrates that its inhibition by Thiorphan and Racecadotril exerts potent antimalarial effects, supporting a host-targeted- therapy approach.

Geeta Kumari
Pragya Gupta
Shailja Singh
ResearchOpen Access11 May 2025
Communications Biology

Volume: 8, P: 1-14
Correction: Blood RNA analysis can increase clinical diagnostic rate and resolve variants of uncertain significance

Htoo A. Wai
Jenny Lord
L. Archer
Amendments and CorrectionsOpen Access01 Apr 2020
Genetics in Medicine

Volume: 22, P: 1129
An N-glycome tissue atlas of 15 human normal and cancer tissue types determined by MALDI-imaging mass spectrometry

Elizabeth N. Wallace
Connor A. West
Richard R. Drake
ResearchOpen Access04 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Spatial omics-based machine learning algorithms for the early detection of hepatocellular carcinoma

Wang et al. apply a spatial omics N-glycan imaging method to identify altered glycosylation in hepatocellular cancer tissue and matched serum samples identifying alteration in over 50 proteins. Machine learning biomarker algorithms developed through multi-protein glycan analysis could serve as potential biomarkers for early detection.

Mengjun Wang
Stephane Grauzam
Anand S. Mehta
ResearchOpen Access03 Dec 2024
Communications Medicine

Volume: 4, P: 1-11
Blood RNA analysis can increase clinical diagnostic rate and resolve variants of uncertain significance

Htoo A. Wai
Jenny Lord
L. Archer
ResearchOpen Access03 Mar 2020
Genetics in Medicine

Volume: 22, P: 1005-1014
Molecular viral oncology of hepatocellular carcinoma

Timothy M Block
Anand S Mehta
Robert Jordan
Reviews11 Aug 2003
Oncogene

Volume: 22, P: 5093-5107
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Amendments and Corrections17 Jul 2020
Nature

Volume: 584, P: E2
Integrating age, BMI, and serum N-glycans detected by MALDI mass spectrometry to classify suspicious mammogram findings as benign lesions or breast cancer

Calvin R. K. Blaschke
Elizabeth G. Hill
Richard R. Drake
ResearchOpen Access02 Dec 2022
Scientific Reports

Volume: 12, P: 1-10
Collagen fiber regulation in human pediatric aortic valve development and disease

Cassandra L. Clift
Yan Ru Su
Peggi M. Angel
ResearchOpen Access07 May 2021
Scientific Reports

Volume: 11, P: 1-17
Modified plant architecture integrated with liquid fertilizers improves fruit productivity and quality of tomato in North West Himalaya, India

Avinash Chandra Rathore
Harsh Mehta
M. Madhu
ResearchOpen Access20 Sept 2021
Scientific Reports

Volume: 11, P: 1-12
Antibiotic Resistome Biomarkers associated to the Pelagic Sediments of the Gulfs of Kathiawar Peninsula and Arabian Sea

Chandrashekar Mootapally
Neelam M. Nathani
Chaitanya G. Joshi
ResearchOpen Access21 Nov 2019
Scientific Reports

Volume: 9, P: 1-12
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access15 Feb 2019
Nature Communications

Volume: 10, P: 1-4
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access02 May 2019
Nature Communications

Volume: 10, P: 1-4
Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis

Bryan Tan
Xin-Hui Pan
Yip Han Chin
Reviews31 May 2023
International Journal of Obesity

Volume: 47, P: 677-685
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

Search

Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking

Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Value addition to dietetic frozen yoghurt through use of fruit peel solids

Fusarium Wilt of Guava (Psidium guyava L.) in Uttar Pradesh, India

Finite element study of the efficacy of three different loops for bodily protraction of the mandibular molar

Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

Does earning money empower women? Evidence from India

QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration

The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants

Identification of essential genes for cancer immunotherapy

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

A second update on mapping the human genetic architecture of COVID-19

PEPlife: A Repository of the Half-life of Peptides

Prediction of hemolytic peptides and their hemolytic concentration

Intrinsic hepatocyte dedifferentiation is accompanied by upregulation of mesenchymal markers, protein sialylation and core alpha 1,6 linked fucosylation

CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing

Prevalence and architecture of de novo mutations in developmental disorders

CRISPR/Cas9-engineering of Kell null erythrocytes to unveil host targeted irresistible antimalarial

Correction: Blood RNA analysis can increase clinical diagnostic rate and resolve variants of uncertain significance

An N-glycome tissue atlas of 15 human normal and cancer tissue types determined by MALDI-imaging mass spectrometry

Spatial omics-based machine learning algorithms for the early detection of hepatocellular carcinoma

Blood RNA analysis can increase clinical diagnostic rate and resolve variants of uncertain significance

Molecular viral oncology of hepatocellular carcinoma

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Integrating age, BMI, and serum N-glycans detected by MALDI mass spectrometry to classify suspicious mammogram findings as benign lesions or breast cancer

Collagen fiber regulation in human pediatric aortic valve development and disease

Modified plant architecture integrated with liquid fertilizers improves fruit productivity and quality of tomato in North West Himalaya, India

Antibiotic Resistome Biomarkers associated to the Pelagic Sediments of the Gulfs of Kathiawar Peninsula and Arabian Sea

Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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