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Showing 1–50 of 54 results

Advanced filters: Author: Andrew Conn Clear advanced filters

Vivisectionists strike back

The complex issue of animal experimentation should not be dumbed down in the face of violent opposition, argues Andrew Read, reviewing a new polemic on the US experience.

Andrew Read
Books & Arts28 May 2008
Nature

Volume: 453, P: 592-593
Changes in brain connectivity and neurovascular dynamics during dexmedetomidine-induced loss of consciousness

Multimodal neuroimaging in humans reveals how the brain’s connectivity and neurovascular dynamics change, as it transitions from wakefulness to dexmedetomidine-induced unconsciousness and then early-stage recovery of consciousness.

Panagiotis Fotiadis
Andrew R. McKinstry-Wu
Dani S. Bassett
ResearchOpen Access20 Aug 2025
Communications Biology

Volume: 8, P: 1-17
Global diversity and distribution of antibiotic resistance genes in human wastewater treatment systems

Wastewater treatment plants are important reservoirs of antibiotic resistance genes (ARGs). Here, the authors analyze ARGs in a global collection of samples from wastewater treatment plants across six continents, providing insights into biotic and abiotic mechanisms that appear to control ARG diversity and distribution.

Congmin Zhu
Linwei Wu
Jizhong Zhou
ResearchOpen Access29 Apr 2025
Nature Communications

Volume: 16, P: 1-14
Knowledge of idiopathic normal pressure hydrocephalus among healthcare professionals

Rocío Fernández-Méndez
Toby Meek
Alexis J. Joannides
ResearchOpen Access15 Aug 2025
Scientific Reports

Volume: 15, P: 1-9
N⁴-substituted N¹-(3-Dimethylaminopropyl)-piperazines : a New Series of Compounds active against Trypanosoma cruzi Infections in Mice

ANDREW S. TOMCUFCIK
REDGINAL I. HEWITT
JOSEPH ENTWISTLE
Research06 Feb 1965
Nature

Volume: 205, P: 605-606
A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis

Many diseases, such as rheumatoid arthritis, are characterized by a chronic inflammatory state, but it is not clear whether or how this affects the brain. Here, the authors show that the severity of on-going inflammation predicts altered functional brain connectivity in people with rheumatoid arthritis.

Andrew Schrepf
Chelsea M. Kaplan
Neil Basu
ResearchOpen Access08 Jun 2018
Nature Communications

Volume: 9, P: 1-11
Hybrid diacrylate resin-gelatin methacryloyl composite with bone-to-brain stiffness range

Biointerfacing techniques face challenges in stiffness matching at interfaces between hard and soft tissues, crucial for advanced biomechanical applications. Here, a 3D printable, biocompatible composite is developed that achieves a wide range of elastic moduli from 15 kPa to 1.4 GPa.

Mohammad Naghavi Zadeh
Kapil D. Patel
Jonathan Rossiter
ResearchOpen Access02 Oct 2025
Communications Materials

Volume: 6, P: 1-14
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

Ke Shuai
Andrew Ziemiecki
James E. Darnell
Research09 Dec 1993
Nature

Volume: 366, P: 580-583
Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors

Zafar I. Bashir
Zuner A. Bortolotto
Graham L. Collingridge
Research27 May 1993
Nature

Volume: 363, P: 347-350
Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression

The neural substrates of depression may differ by sex. Here the authors show that depression is associated with distinct brain connectivity changes in men and in women that are explained by sex-specific transcriptomic signatures involving genes previously implicated in synapse function, immune signalling, and depression risk.

Aleksandr Talishinsky
Jonathan Downar
Conor Liston
ResearchOpen Access28 Sept 2022
Nature Communications

Volume: 13, P: 1-20
Central Executive Network drives delta-9-tetrahydrocannabinol (THC)-induced nonlinear changes in large-scale functional connectivity in adolescent nonhuman primates

Andrew Jin Soo Byun
Harshawardhan U. Deshpande
Stephen J. Kohut
Research28 Feb 2025
Neuropsychopharmacology

Volume: 50, P: 1743-1751
Insertion of DNA activates the cryptic bgl operon in E. coli K12

Ann E. Reynolds
Jeffrey Felton
Andrew Wright
Research22 Oct 1981
Nature

Volume: 293, P: 625-629
Semiconductor devices

Andrew Holmes-Siedle
Books & Arts02 Mar 1978
Nature

Volume: 272, P: 108
Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

Osteoarthritis has been believed to be caused by improper mechanical function of articular joints. Xu Cao and his colleagues now show that this mechanical process leads to upregulation of transforming growth factor β1 activity in mesenchymal stem cells of subchondral bone, resulting in aberrant bone formation, further destabilization of the joint and ultimately the onset of the disease.

Gehua Zhen
Chunyi Wen
Xu Cao
Research19 May 2013
Nature Medicine

Volume: 19, P: 704-712
Mgl2⁺ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice

Fungal spores can promote immune responses of both type 2 (IL-4 / IL-5 / IL-13) and type 17 (IL-17). Here the authors characterise the subsets of cDC2 associated with type 2 and type 17 allergic responses to fungal allergens and show that Mgl2⁺ cDC2 depletion reduces type 2 but not type 17 fungal airway inflammation.

Peter C. Cook
Sheila L. Brown
Andrew S. MacDonald
ResearchOpen Access22 Jan 2025
Nature Communications

Volume: 16, P: 1-18
Immuno-gold localization of leghaemoglobin in cytoplasm in nitrogen-fixing root nodules of pea

John G. Robertson
Brian Wells
Andrew W. B. Johnston
Research20 Sept 1984
Nature

Volume: 311, P: 254-256
NEAR-DROWNING IN BRITISH COLUMBIA

Andrew J Macnab
David F Wensley
Judith G Hall
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 203
Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana

Athanasios Theologis
Joseph R. Ecker
Ronald W. Davis
Research14 Dec 2000
Nature

Volume: 408, P: 816-820
Insights from exome sequencing for endocrine disorders

Whole-exome sequencing (WES) can effectively sequence >90% of the coding DNA in an individual, and reveal potential disease-causing genetic variants. In this Review, de Bruin and Dauber discuss the use of WES in the field of endocrinology, how this technique can reveal new insights into both rare and common disorders, and its future use in a clinical environment.

Christiaan de Bruin
Andrew Dauber
Reviews12 May 2015
Nature Reviews Endocrinology

Volume: 11, P: 455-464
Ultralong lifetime and efficient room temperature phosphorescent carbon dots through multi-confinement structure design

For room temperature phosphorescence (RTP) materials to reach their potential for optical applications, new materials with improved performance must be realized. Here, the authors report multi-confined carbon dots as high stability RTP materials with long afterglow lifetime & high efficiency.

Yuqiong Sun
Shuting Liu
Mingtao Zheng
ResearchOpen Access05 Nov 2020
Nature Communications

Volume: 11, P: 1-11
Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory Reconsolidation

Adam G Walker
Douglas J Sheffler
P Jeffrey Conn
Research30 Jun 2017
Neuropsychopharmacology

Volume: 42, P: 2553-2566
The Distribution of Fluid Intake from Mist Tent Therapy

Norman Aspin
Samuel K Bau
Andrew Sass-Kortsak
Research01 Sept 1970
Pediatric Research

Volume: 4, P: 478
Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of ere recombinase

Andrew I. Brooks
Bhaskar Muhkerjee
Howard J. Federoff
Research01 Jan 1997
Nature Biotechnology

Volume: 15, P: 57-62
Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving

Accumulation of calcium-permeable AMPA receptors at nucleus accumbens synapses underlies the intensified cue-induced cocaine craving observed after prolonged withdrawal, a phenomenon that may contribute to relapse. Here, Loweth and colleagues find that administration of mGluR1 positive allosteric modulators can normalize accumbens AMPAR transmission and curb cocaine craving in rats.

Jessica A Loweth
Andrew F Scheyer
Marina E Wolf
Research24 Nov 2013
Nature Neuroscience

Volume: 17, P: 73-80
Author Correction: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

Feven Tameire
Ioannis I. Verginadis
Constantinos Koumenis
Amendments and Corrections17 Jul 2019
Nature Cell Biology

Volume: 21, P: 1052
Inflammation is associated with avolition and reduced resting state functional connectivity in corticostriatal reward circuitry in patients with schizophrenia

David R. Goldsmith
Courtney S. Ning
Andrew H. Miller
Research24 Apr 2025
Neuropsychopharmacology

Volume: 50, P: 1706-1714
HIGH RISK PAEDIATRIC INTER-HOSIPTAL TRANSPORT

Andrew J Macnab
David F Wensley
Judith G Hall
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 203
Binge Alcohol Drinking by Mice Requires Intact Group1 Metabotropic Glutamate Receptor Signaling Within the Central Nucleus of the Amygdale

Debra K Cozzoli
Justin Courson
Karen K Szumlinski
Research21 Aug 2013
Neuropsychopharmacology

Volume: 39, P: 435-444
Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles

Jerri M Rook
Mohammed N Tantawy
P Jeffrey Conn
Research22 Sept 2014
Neuropsychopharmacology

Volume: 40, P: 755-765
Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects

Robert W Gould
Russell J Amato
Carrie K Jones
Research28 Aug 2015
Neuropsychopharmacology

Volume: 41, P: 1166-1178
ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

Activating transcription factor 4 (ATF4) promotes MYC-driven tumour progression. Tameire et al. identify ATF4 and its target eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) as regulators of MYC-mediated amino acid biosynthesis and protein synthesis, thereby modulating tumour progression and survival in mice.

Feven Tameire
Ioannis I. Verginadis
Constantinos Koumenis
Research01 Jul 2019
Nature Cell Biology

Volume: 21, P: 889-899
The psychological correlates of distinct neural states occurring during wakeful rest

Theodoros Karapanagiotidis
Diego Vidaurre
Jonathan Smallwood
ResearchOpen Access03 Dec 2020
Scientific Reports

Volume: 10, P: 1-11
Sleep spindle architecture associated with distinct clinical phenotypes in older adults at risk for dementia

Isabella F. Orlando
Claire O’Callaghan
Sharon L. Naismith
ResearchOpen Access05 Dec 2023
Molecular Psychiatry

Volume: 29, P: 402-411
Post-natal transient cataracts in pre-term infants

Peter Hahn
Andrew Q Mccormick
Sydney Segal
Research01 Aug 1971
Pediatric Research

Volume: 5, P: 412
1499 ROLE OF O₂-HEMOGLOBIN AFFINITY ON THE RESPONSE TO HYPOXIA OF CEREBRAL BLOOD FLOW IN THE FETAL SHEEP

Adam A Rosenberg
Andrew Harris
M Douglas Jones Jr.
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 360
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
Elevated caudate connectivity in cognitively normal Parkinson’s disease patients

Natalie Wright
Abrar Alhindi
Ji Hyun Ko
ResearchOpen Access21 Oct 2020
Scientific Reports

Volume: 10, P: 1-9
Global connectivity and local excitability changes underlie antidepressant effects of repetitive transcranial magnetic stimulation

Neir Eshel
Corey J. Keller
Amit Etkin
Research13 Feb 2020
Neuropsychopharmacology

Volume: 45, P: 1018-1025
Rapid treatment of moderate to severe hypertension using a novel protocol in a single-centre, before and after interventional study

Andrew N. Jordan
Christine Anning
Andrew S. P. Sharp
Research23 Oct 2019
Journal of Human Hypertension

Volume: 34, P: 165-175
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Replication-restricted vaccinia as a cytokine gene therapy vector in cancer: Persistent transgene expression despite antibody generation

Sutapa Mukherjee
Thomas Haenel
Bruce Robinson
Research15 Jun 2000
Cancer Gene Therapy

Volume: 7, P: 663-670
SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND DERMATITIS HERPETIFORMIS (OH) IN A GIRL WITH MARFAN'S SYNDROME

Andrew J Aronson
Keyoumars Soltani
Burton J Grossman
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 484
Hdac3 deletion in myeloid progenitor cells enhances bone healing in females and limits osteoclast fusion via Pmepa1

David H. H. Molstad
Elizabeth Zars
Elizabeth W. Bradley
ResearchOpen Access11 Dec 2020
Scientific Reports

Volume: 10, P: 1-15
Neuroimaging correlates and predictors of response to repeated-dose intravenous ketamine in PTSD: preliminary evidence

Agnes Norbury
Sarah B. Rutter
Adriana Feder
Research31 Jul 2021
Neuropsychopharmacology

Volume: 46, P: 2266-2277
Mechanical loading recovers bone but not muscle lost during unloading

Andrew R. Krause
Toni A. Speacht
Henry J. Donahue
ResearchOpen Access03 Dec 2020
npj Microgravity

Volume: 6, P: 1-8
An open science resource for establishing reliability and reproducibility in functional connectomics

Xi-Nian Zuo
Jeffrey S Anderson
Michael P Milham
ResearchOpen Access09 Dec 2014
Scientific Data

Volume: 1, P: 1-13
Psilocybin increases optimistic engagement over time: computational modelling of behaviour in rats

Elizabeth L. Fisher
Ryan Smith
Claire J. Foldi
ResearchOpen Access30 Sept 2024
Translational Psychiatry

Volume: 14, P: 1-10
Effects of the 5-HT_2C/2B Antagonist SB 206553 on Hyperactivity Induced by Cocaine

Andrew C McCreary
Kathryn A Cunningham
Research01 Jun 1999
Neuropsychopharmacology

Volume: 20, P: 556-564
Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition

Logan G. Kavanaugh
Andrew R. Mahoney
Graeme L. Conn
ResearchOpen Access06 Oct 2023
npj Antimicrobials and Resistance

Volume: 1, P: 1-16

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