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Economists must improve tools to weigh trade-offs between health and wealth, says Andy Haldane.

Traditionally, ozone has been primarily used to oxidatively deconstruct carbon–carbon bonds. Now, it has been shown that ozone can be used for the construction of carbon–oxygen bonds without oxidative cleavage of the olefin substrate through capturing primary ozonides. Furthermore, intercepting primary ozonides with nucleophiles in continuous flow enabled the green, syn-dihydroxylation of olefins to be realized.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Potential ligand class-dependent differences in STING activation have both evolutionary and therapeutic implications. Here, the authors observe a unique oligomerization state of STING with an open-LBD ligand, suggesting additional regulatory mechanisms involved in activation by this ligand class.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

Availability of computing power can limit computational analysis of large genetic and genomic datasets. Here, Canela-Xandri, et al. describe a software called DISSECT that is capable of analyzing large-scale genetic data by distributing the work across thousands of networked computers.

Immunotherapy has yet to demonstrate efficacy for patients with glioblastoma. Here, the authors employ human single-cell RNA-seq, spatial transcriptomics, and a preclinical mouse model to show that glioblastoma cell-derived synaptogenic factor Thrombospondin-1 promotes neuronal circuit remodeling and regional immunosuppression, highlighting a potential therapeutic target.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

Citizen science taps the efforts of non-experts. Here, authors describe Drugit, an extension of the crowdsourcing game Foldit, and its use in designing a non-peptide binder of Von Hippel Lindau E3 ligase for use with proteolysis targeting chimeras.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

A multi-omics approach reveals host–microbiome interactions in aging in mice.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Quantum error correction of a logical qutrit and ququart were experimentally realized beyond the break-even point with the Gottesman–Kitaev–Preskill bosonic code.

Testicular aging affects male reproductive health. Here, the authors show that impaired ketogenesis in Leydig cells drives testicular aging, and boosting ketogenesis or supplementing with the ketone body BHB can help mitigate testicular aging.

Spin-current-induced magnetization reversal of a perpendicularly magnetized thulium iron garnet film is reported. The spin current is driven by the current flowing through a Pt overlayer.

The carbon cycle plays a central role in climate change. An analytical framework shows that the influence of atmospheric carbon dioxide concentrations on climate is more sensitive to carbon perturbations now than it has been over much of the preceding 400 million years.

Expanding the scope of materials for spin caloritronics enhances the opportunity to achieve more energy efficient memory and sensor devices. Here the authors report the tunnel magneto-Seebeck effects in magnetic tunnel junctions with Co₂FeAl and Co₂FeSi Heusler compounds.

A brief period of warming 55.9 Myr ago has been attributed to the release of massive amounts of carbon. Geochemical and model data suggest the peak rate of carbon emission during this interval was relatively slow, and significantly lower than present-day levels of carbon emissions to the atmosphere.

Changes in Arctic sea ice volume are difficult to quantify. Five years of satellite data reveal a reduction in autumn sea ice volume in 2010–2012, but a sharp increase in 2013 and 2014, suggesting that ice volume can recover quickly.

The authors assess the risk of overshoot beyond 1.5 °C warming, using three scenarios with minimal overshoot, brief overshoot and sustained overshoot. They show a risk of long-term Amazon dieback, which begins as early as 1.3 °C warming but is largely mitigated by reducing temperature below 1.5 °C.

Carbon release rates during the Palaeocene–Eocene Thermal Maximum are difficult to constrain. Comparing relative rates of carbon cycle and climate change at the event’s onset suggests emissions were much slower than anthropogenic emissions.

Plant RNA Pol V is involved in the RNA-directed DNA-methylation pathway that leads to heterochromatic silencing at some endogenous loci. Now the genomic regions targeted by Pol V in Arabidopsis thaliana are determined by ChIP-seq analyses revealing Pol V's enrichment at evolutionarily recent transposons.

Terahertz radiation is used to directly probe magnetotransport in metallic multilayers on the timescale of electron momentum scattering—the fundamental conditions of Nevill Mott’s model of spin-dependent conduction in metals.

It is now shown that femtosecond optical excitation can be used as a tool to investigate the spin-polarization properties of half-metals, and provide a clear distinction between those and metals. Such knowledge is of fundamental importance for the use of these materials in spintronics applications.

The genetic diversity of wild relatives of domesticated crops can be useful for developing more productive, nutritious and resilient crop varieties. A comparison of the modelled diversity of crop wild relatives with their representation in gene banks suggests that a systematic effort is needed to improve their conservation and availability for use in plant breeding.

DNA double-strand breaks induce local genome maintenance and inhibition of replication initiation at nearby topologically associating domains without affecting global DNA synthesis.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Genome-wide ancient DNA data from individuals from the Middle Bronze Age to Iron Age documents large-scale movement of people from the European continent between 1300 and 800 bc that was probably responsible for spreading early Celtic languages to Britain.

Nitric oxide is an environmental pollutant that is typically remediated by selective catalytic reduction at elevated temperatures. Here an electrochemical oxidation pathway is reported at near-ambient conditions, producing a concentrated stream of nitric acid as a valuable product from waste nitric oxide streams.

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary statistics from diverse populations.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Fan and colleagues show that FLASH radiation promotes proinflammatory polarization of tumor-associated macrophages, which in turn increases T cell influx in medulloblastoma and synergizes with CAR-T cell therapy.

Chromatin topology can impact gene regulation. Here, Wu et al. show that evolutionary changes in chromatin structure, particularly CTCF loops, can drive distinct transcriptional landscapes and isoform diversity contributing to human-specific traits.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Integrating incomplete multi-omics data remains a key challenge in precision oncology. IntegrAO, an unsupervised framework that integrates diverse omics, enables accurate patient classification even with incomplete datasets.