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An NLR pair in the Pm68 locus confers powdery mildew resistance in durum and common wheat

Powdery mildew is a devasting disease for both common wheat and durum wheat. Here, the authors report a pair of genetically linked nucleotide-binding leucine-rich repeat (NLR)-encoding genes confer powdery mildew resistance and show its potential in wheat disease-resistant breeding.

Huagang He
Qiulian Tang
Yajun Wang
ResearchOpen Access10 Oct 2025
Nature Communications

Volume: 16, P: 1-12
A global analysis of dairy consumption and incident cardiovascular disease

The role of dairy products in cardiovascular disease (CVD) prevention is debated. Here, the authors show that dairy consumption is associated with a lower risk of CVD and stroke, with cheese linked to reduced CVD risk, though the effects vary between Chinese and UK populations.

Pan Zhuang
Xiaohui Liu
Jingjing Jiao
ResearchOpen Access06 Jan 2025
Nature Communications

Volume: 16, P: 1-13
p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line

Anli Jiang
Chunxiao Yu
Jianye Zhang
ResearchOpen Access01 Dec 2006
Experimental & Molecular Medicine

Volume: 38, P: 625-633
Author Correction: Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

Chuanhui Han
Zhida Liu
Yang-Xin Fu
Amendments and Corrections16 Sept 2020
Nature Immunology

Volume: 21, P: 1470
Erratum: Follicular CXCR5-expressing CD8⁺ T cells curtail chronic viral infection

Ran He
Shiyue Hou
Lilin Ye
Amendments and Corrections19 Oct 2016
Nature

Volume: 540, P: 470
A kinase fusion protein from Aegilops longissima confers resistance to wheat powdery mildew

The powdery mildew resistance gene Pm13 was introgressed into wheat from Aegilops longissima. Here, the authors report the cloning of Pm13 and reveal that it encodes a MLKL_NTD domain-containing kinase.

Huagang He
Zhaozhao Chen
Yajun Wang
ResearchOpen Access02 Aug 2024
Nature Communications

Volume: 15, P: 1-13
Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

Therapeutic irradiation can trigger DNA-sensing pathways and trigger antitumor immunity. Fu and colleagues demonstrate that tumors can co-opt intrinsic apoptotic pathways to avoid immunogenic cell death following irradiation.

Chuanhui Han
Zhida Liu
Yang-Xin Fu
Research30 Mar 2020
Nature Immunology

Volume: 21, P: 546-554
The effects of water content and fracture angle on rock creep and crack behavior under impact conditions

Guixing Yuan
Jianhua Deng
Anli Wang
ResearchOpen Access05 Mar 2025
Scientific Reports

Volume: 15, P: 1-21
Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis

The application of STING agonists and the blockade of the SIRPα–CD47 signaling axis are emerging immunotherapeutic strategies. Here the authors show that hybrid cellular membrane nanovesicles loaded with a STING agonist or overexpressing high-affinity SIRPα variants can be exploited to promote anti-tumor immune responses.

Lang Rao
Lei Wu
Xiaoyuan Chen
ResearchOpen Access30 Sept 2020
Nature Communications

Volume: 11, P: 1-13
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

Improper innate sensing within the tumor microenvironment limits immunotherapy success. Here, the authors show that targeting NQO1 triggers immunogenic innate sensing to reactivate T cells and overcome immune checkpoint blockade resistance.

Xiaoguang Li
Zhida Liu
Yang-Xin Fu
ResearchOpen Access19 Jul 2019
Nature Communications

Volume: 10, P: 1-13
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8⁺ T cells to overcome immunotherapy resistance in cancer

Bae et al. engineer mesenchymal stem cells to express and deliver IL-2 to tumour-infiltrating lymphocytes, leading to activation and expansion of CD8⁺ T cells and improved tumour control, overcoming adaptive resistance to immune checkpoint blockade.

Joonbeom Bae
Longchao Liu
Yang-Xin Fu
Research06 Dec 2022
Nature Cell Biology

Volume: 24, P: 1754-1765
Follicular CXCR5-expressing CD8⁺ T cells curtail chronic viral infection

A population of partially exhausted CXCR5⁺ CD8⁺ T cells, induced by chronic virus infection and residing in B-cell follicles, is shown to control viral replication.

Ran He
Shiyue Hou
Lilin Ye
Research02 Aug 2016
Nature

Volume: 537, P: 412-416
Anxiety, home blood pressure monitoring, and cardiovascular events among older hypertension patients during the COVID-19 pandemic

Shuyuan Zhang
Yixuan Zhong
Weili Zhang
ResearchOpen Access21 Jan 2022
Hypertension Research

Volume: 45, P: 856-865
A comparative analysis of toxicity and treatment outcomes of adaptive radiotherapy and intensity-modulated radiotherapy in cervical cancer

Xiaohan Liu
Wei Tian
Zemin Xiao
ResearchOpen Access10 Jan 2025
Scientific Reports

Volume: 15, P: 1-9
Histidine-trytophan-ketoglutarate cardioplegia reduces inflammatory response and serum levels of myocardial enzymes in newly developed right-thoracotomy rat model

BingMei Qiu
Lei Wang
ShanWu Feng
ResearchOpen Access22 Oct 2024
Scientific Reports

Volume: 14, P: 1-15
Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8⁺ T cells

Xue Wang
Longchao Liu
Yang-Xin Fu
ResearchOpen Access12 Jul 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-3
Deciphering transcriptome alterations in bone marrow hematopoiesis at single-cell resolution in immune thrombocytopenia

Yan Liu
Xinyi Zuo
Jun Peng
ResearchOpen Access07 Oct 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-18
IL6 blockade potentiates the anti-tumor effects of γ-secretase inhibitors in Notch3-expressing breast cancer

Dong Wang
Jiahui Xu
Suling Liu
Research13 Oct 2017
Cell Death & Differentiation

Volume: 25, P: 330-339
Small molecular drugs reshape tumor microenvironment to synergize with immunotherapy

Chuanhui Han
Anli Zhang
Yang-Xin Fu
Reviews07 Dec 2020
Oncogene

Volume: 40, P: 885-898

Search

An NLR pair in the Pm68 locus confers powdery mildew resistance in durum and common wheat

A global analysis of dairy consumption and incident cardiovascular disease

p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line

Author Correction: Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

Erratum: Follicular CXCR5-expressing CD8⁺ T cells curtail chronic viral infection

A kinase fusion protein from Aegilops longissima confers resistance to wheat powdery mildew

Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

The effects of water content and fracture angle on rock creep and crack behavior under impact conditions

Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8⁺ T cells to overcome immunotherapy resistance in cancer

Follicular CXCR5-expressing CD8⁺ T cells curtail chronic viral infection

Anxiety, home blood pressure monitoring, and cardiovascular events among older hypertension patients during the COVID-19 pandemic

A comparative analysis of toxicity and treatment outcomes of adaptive radiotherapy and intensity-modulated radiotherapy in cervical cancer

Histidine-trytophan-ketoglutarate cardioplegia reduces inflammatory response and serum levels of myocardial enzymes in newly developed right-thoracotomy rat model

Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8⁺ T cells

Deciphering transcriptome alterations in bone marrow hematopoiesis at single-cell resolution in immune thrombocytopenia

IL6 blockade potentiates the anti-tumor effects of γ-secretase inhibitors in Notch3-expressing breast cancer

Small molecular drugs reshape tumor microenvironment to synergize with immunotherapy

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