The ATM signalling mediator proteins 53BP1 and KAP-1 are required for heterochromatic double-strand break DNA repair. 53BP1 aids Mre11, NBS1 and ATM accumulation at heterochromatic breaks, leading to localized phosphorylation of KAP-1 by ATM.
- Angela T. Noon
- Atsushi Shibata
- Aaron A. Goodarzi