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Polygenic risk scores can help identify individuals at higher risk of type 2 diabetes. Here, the authors characterise a multi-ancestry score across nearly 900,000 people, showing that its predictive value depends on demographic and clinical context and extends to related traits and complications.

Observed 730 Myr after the Big Bang, a little red dot is found to anchor an overdensity of eight galaxies and seems to be embedded in a massive host dark matter halo.

Greene et al. find that collaborative contact that equalizes the social status of opposing partisans can reduce political polarization.

When people recall a movie, their eye movements and brain activity resemble those observed during the viewing. These behavioral and neural reactivations are linked through a common process, likely reflecting the specific internal experiences that emerge in an instance of recall.

Electric vehicles are increasingly adopted in the USA, with concurrent expansion of charging infrastructure and electricity demand. This Review details these trends and discusses their drivers and broader implications.

Two high-redshift post-starburst galaxies are in the process of quenching, although their quasars remain active, indicating the complex co-evolution between black hole activity and star formation.

DNA-binding proteins need to scan the genome to find their targets though how this occurs in the crowded nuclear environment is poorly understood. Here the authors use single-molecular fluorescence to show the repair complex Msh2-Msh3 can hop over blocks that impede the sliding complex Msh2-Msh6.

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

The masses of supermassive black holes are known to correlate with the properties of the bulge components of their host galaxies. In contrast, they appear not to correlate with galaxy disks. Disk-grown pseudobulges are intermediate in properties between bulges and disks. This paper reports pseudobulge classifications for a sample of nearby galaxies, and combines them with recent measurements of velocity dispersions in the biggest bulgeless galaxies to confirm that black holes do not correlate with disks, and that they correlate little or not at all with pseudobulges.

Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

Oestrogen negative breast cancer is associated with a poor prognosis. In this study, the authors perform a meta-analysis of 11 breast cancer genome-wide association studies and identify four new loci associated with oestrogen negative breast cancer risk. These findings may aid in stratifying patients in the clinic.

JWST/NIRSpec observations of Abell2744-QSO1 show a high black-hole-to-host mass ratio in the early Universe, which indicates that we are seeing the black hole in a phase of rapid growth, accreting at 30% of the Eddington limit.

An analysis of eight ultra-faint galaxies during the epoch of reionization with absolute magnitudes between −17 mag and −15  mag shows that most of the photons that reionized the Universe come from dwarf galaxies.

Over 170 susceptibility loci have been identified by genome-wide association studies in breast cancer. Here, the authors interrogated the role of risk-associated variants from non-breast tissue, and using expression quantitative trait loci, identify potential target genes of known breast cancer susceptibility variants, as well as 11 regions not previously known to be associated with breast cancer risk.

Two below-threshold surface code memories on superconducting processors markedly reduce logical error rates, achieving high efficiency and real-time decoding, indicating potential for practical large-scale fault-tolerant quantum algorithms.

Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.

A study establishes a scalable approach to engineer and characterize a many-body-localized discrete time crystal phase on a superconducting quantum processor.

The transcription machinery must locate specific promoter sequences among a vast excess of nonspecific DNA. Real-time single-molecule experiments with E. coli RNA polymerase, combined with theoretical calculations, suggest that facilitated diffusion does not contribute to promoter targeting at physiologically relevant protein concentrations but that instead the promoter search is dominated by three-dimensional diffusion.

Preliminary and exploratory analyses show that a third dose of the COVID-19 vaccine mRNA-1273 or variant-modified boosters can boost levels of neutralizing antibodies against SARS-CoV-2 variants.

Gold nanowires conjugated with a cytokine can be transported to specific cells with high precision using electrophoretic and dielectrophoretic forces.

A third dose of the COVID-19 vaccine mRNA-1273 is safe and boosts SARS-CoV-2 neutralizing antibody titers almost two-fold higher than the peak levels observed after completion of a two-dose series, highlighting the potential clinical benefit of a booster dose.

Electrons in the non-superconducting state of cuprates can exhibit unusual transport behaviour. Now, analysis of experimental data shows that the magnetoresistance in this state is conventional, but influenced by an anisotropic scattering rate.

Low frequency intrinsic ocean variability has an unknown impact on Antarctic ice shelves, yet can arise even in the absence of varying climate forcing. Here, the authors show that this variability significantly affects modelled basal melting under the Totten Ice Shelf, with implications for the attribution of change.

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

PIWI-interacting RNAs (piRNAs) suppress transposon and gene expression during development. Here, the authors identify many piRNAs and piRNA-like small RNAs in 11 human cell lines, and show that one piRNA-like small RNA binds to phosphorylated ERM proteins to regulate cancer cell migration and invasion.

Supermassive black holes have been detected in all galaxies that contain bulge components. Bigger black holes are found in bigger bulges, implying that black-hole growth and bulge formation regulate each other. Reports of a similar correlation between black holes and the dark matter haloes suggest that unknown, exotic physics controls black-hole growth. Here it is shown that there is almost no correlation between dark matter and parameters that measure black holes unless the galaxy also contains a bulge. It is concluded that black holes do not correlate directly with dark matter, and that black holes coevolve only with bulges.

Genome-wide analysis identifies 32 loci associated with breast cancer susceptibility, accounting for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status and tumor grade.

Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants and find high genetic correlation between breast cancer risk for BRCA1 mutation carriers and risk of ER-negative breast cancer in the general population.

Repetition codes running many cycles of quantum error correction achieve exponential suppression of errors with increasing numbers of qubits.

An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

We present a consensus-based checklist to improve and document the transparency of research reports in social and behavioural research. An accompanying online application allows users to complete the form and generate a report that they can submit with their manuscript or post to a public repository.

Conventional wisdom tells us that supermassive black holes are found exclusively in massive galaxies undergoing little star formation. But one such object has now been discovered in a star-forming dwarf galaxy. See Letter p.66

In order for quiescent galaxies to maintain their low-to-non-existent star formation, there must be a mechanism to remove or heat gas that would otherwise cool to form stars; now supermassive black hole winds that are sufficient to suppress star formation in such galaxies are reported.