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Showing 1–50 of 1139 results

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Cardiomyocyte-derived USP13 protects hearts from hypertrophy via deubiquitinating and stabilizing STAT1 in male mice

Deubiquitinating enzymes play an essential role in myocardial hypertrophy. Here, the authors show the beneficial effects of a cardiomyocyte-derived deubiquitinating enzyme, USP13, in hypertrophic cardiomyocytes and identify a cardiomyocyte-specific USP13-STAT1 axis in regulating cardiac hypertrophy.

Jibo Han
Liming Lin
Yi Wang
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Inhibition of UCHL1 by LDN-57444 attenuates Ang II–Induced atrial fibrillation in mice

Hai-Lian Bi
Yun-Long Zhang
Hui-Hua Li
ResearchOpen Access07 Nov 2019
Hypertension Research

Volume: 43, P: 168-177
TRPM7 channel activity promotes the pathogenesis of abdominal aortic aneurysms

Zong et al. reveal that genetic and pharmacologic inhibition of TRPM7 channel function prevents the activation of Ca²⁺–CaM–calcineurin–KLF4 signaling, the phenotypic switch of vascular smooth muscle cells and the formation of abdominal aortic aneurysms.

Pengyu Zong
Cindy X. Li
Lixia Yue
Research14 Feb 2025
Nature Cardiovascular Research

Volume: 4, P: 197-215
A repetitive amplitude encoding method for enhancing the mapping ability of quantum neural networks

Ziyang Li
Xiaofei Fu
Ruishan Du
ResearchOpen Access01 Sept 2025
Scientific Reports

Volume: 15, P: 1-32
The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis

Non-ischemic cardiomyopathy is a severe disease, characterized by interstitial fibrosis in the left ventricle of the heart. Here authors show that the E3 ubiquitin ligase WWP2 plays a pathogenic role in heart fibrosis via regulating a distinct monocyte population that initiates the process.

Huimei Chen
Gabriel Chew
Enrico Petretto
ResearchOpen Access30 Nov 2022
Nature Communications

Volume: 13, P: 1-21
Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury

High homocysteine plasma levels are associated with cardiovascular diseases. Here, Li and colleagues find that homocysteine aggravates vascular injury by direct binding to the angiotensin II type 1 receptor (AT1R), identifying AT1R inhibition as a potential strategy to counteract the deleterious vascular effects of hyperhomocysteinemia.

Tuoyi Li
Bing Yu
Wei Kong
ResearchOpen Access02 Jan 2018
Nature Communications

Volume: 9, P: 1-13
Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias

GPCR kinases (GRKs) phosphorylate active-form G-protein-coupled receptors (GPCRs). Here, the authors reveal that Gq heterotrimer coupled with the angiotensin II type-1 receptor (AT1R) determines the GRK subtypes recruited to the complex in a microdomain, thus defining subsequent AT1R phosphorylation patterns, β-arrestin conformation and functionality.

Kouki Kawakami
Masataka Yanagawa
Asuka Inoue
ResearchOpen Access25 Jan 2022
Nature Communications

Volume: 13, P: 1-16
Deciphering biased-agonism complexity reveals a new active AT₁ receptor entity

BRET probes that monitor activation of multiple G protein isoforms reveal that angiotensin II and a biased agonist of the angiotensin II type 1A receptor stabilize distinct receptor conformations associated with different signaling outputs.

Aude Saulière
Morgane Bellot
Céline Galés
Research27 May 2012
Nature Chemical Biology

Volume: 8, P: 622-630
Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes

Han, Fang et al. show that the deubiquitinase JOSD2 deubiquitinates and stabilizes SERCA2a in cardiomyocytes, which results in normalized calcium handling and reduced cardiac pathology under hypertensive stress.

Jibo Han
Zimin Fang
Guang Liang
Research07 Aug 2023
Nature Cardiovascular Research

Volume: 2, P: 764-777
Senescent cells limit p53 activity via multiple mechanisms to remain viable

To develop therapeutics that selectively eliminate pathological senescent cells it is important to understand their survival mechanisms. Here, the authors show that senescent cells manage to survive by keeping p53 activity in check through multiple mechanisms, including inhibitory mechanisms that involve p53 binding to ribonucleases.

Ines Sturmlechner
Chance C. Sine
Jan M. van Deursen
ResearchOpen Access28 Jun 2022
Nature Communications

Volume: 13, P: 1-14
Intravitreal faricimab for diabetic macular oedema and neovascular age-related macular degeneration: general considerations and practical recommendations by an expert panel of Italian retina specialists

Enrico Borrelli
Francesco Boscia
Francesco Bandello
Research25 Sept 2025
Eye

P: 1-10
PASC (Post Acute Sequelae of COVID-19) is associated with decreased neutralizing antibody titers in both biological sexes and increased ANG-2 and GM-CSF in females

Ethan B. Jansen
Ali Toloue Ostadgavahi
Alyson A. Kelvin
ResearchOpen Access29 Apr 2024
Scientific Reports

Volume: 14, P: 1-14
Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT₁ receptor with protective action in cardiac hypertrophy

Larissa B. Teixeira
Lucas T. Parreiras-e-Silva
Claudio M. Costa-Neto
ResearchOpen Access19 Sept 2017
Scientific Reports

Volume: 7, P: 1-10
Association of Ang-(1–7) and des-Arg⁹BK as new biomarkers of obesity and cardiometabolic risk factors in adolescents

Fernanda Barrinha Fernandes
Adriana Barrinha Fernandes
Dulce Elena Casarini
Research10 Feb 2021
Hypertension Research

Volume: 44, P: 969-977
A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction

Ryo Watanabe
Jun-ichi Suzuki
Mitsuaki Isobe
ResearchOpen Access07 Mar 2017
Scientific Reports

Volume: 7, P: 1-13
Endothelial FOSL1 drives angiotensin II-induced myocardial injury via AT1R-upregulated MYH9

Wen-jing Zhao
Yi Qian
Wei-zhong Zhu
Research26 Nov 2024
Acta Pharmacologica Sinica

Volume: 46, P: 922-939
Angiogenetic axis angiopoietins/Tie2 and VEGF in familial breast cancer

K Danza
B Pilato
S Tommasi
Research12 Dec 2012
European Journal of Human Genetics

Volume: 21, P: 824-830
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury

Endogenous ACE2 is a receptor for SARS-CoV-2 and a recombinant soluble ACE2 protein can inhibit SARS-CoV-2 infection acting as a decoy. Here the authors show that B38-CAP, an ACE2-like enzyme but not a decoy for the virus, is protective against SARS-CoV-2-induced lung injury in animal models.

Tomokazu Yamaguchi
Midori Hoshizaki
Keiji Kuba
ResearchOpen Access23 Nov 2021
Nature Communications

Volume: 12, P: 1-13
MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice

MiR-126-5p expression decreases abdominal aorta dilation in mice with Ang II-induced abdominal aortic aneurysm (AAA), and its agomirs limit experimental AAA formation. MiR-126-5p inhibits Ang II- and PDGF-BB-induced dedifferentiation of aortic smooth muscle cells (AoSMCs) in vitro. MiR-126-5p promotes contractile switching of AoSMCs exposed to Ang II by targeting VEPH1.

Xiaofeng Shi
Wei Ma
Lei Li
Research01 Jul 2020
Laboratory Investigation

Volume: 100, P: 1564-1574
Ambient pressure storage of high-density methane in nanoporous carbon coated with graphene

High-density methane storage typically requires high pressures and/or low temperatures, which can pose operational challenges. Here the authors report graphene-coated carbons that, after high-pressure charging, can store methane at high densities even at ambient external pressure.

Shuwen Wang
Fernando Vallejos-Burgos
Katsumi Kaneko
Research23 May 2025
Nature Energy

Volume: 10, P: 847-856
Direct stimulation of Jak/STAT pathway by the angiotensin II AT₁ receptor

Mario B. Marrero
Bernhard Schieffer
Kenneth E. Bernstein
Research18 May 1995
Nature

Volume: 375, P: 247-250
Convergent evolution of diverse jaw joints in mammaliamorphs

High-resolution computed tomography is used to reconstruct and analyse fossils of the herbivorous tritylodontid Polistodon and a newly named morganucodontid species called Camurocondylus, providing key insights into the evolution of the mammalian jaw joint.

Fangyuan Mao
Shan Jiang
Jin Meng
Research24 Sept 2025
Nature

P: 1-8
Stimulation of the ACE2/Ang-(1–7)/Mas axis in hypertensive pregnant rats attenuates cardiovascular dysfunction in adult male offspring

Amanda S. M. Bessa
Érika F. Jesus
Carlos H. Castro
Research10 Sept 2019
Hypertension Research

Volume: 42, P: 1883-1893
SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway

The hyperproliferation of vascular smooth muscle cells underlies many vascular diseases. Here Xieet al. show that the splicing factor SRSF1 is an endogenous stimulator of human and mouse aortic smooth muscle cell proliferation via the Δ133p53/EGR1/KLF5 signalling axis, identifying potential therapeutic targets for vascular proliferative disorders.

Ning Xie
Min Chen
Chun-Mei Cao
ResearchOpen Access11 Aug 2017
Nature Communications

Volume: 8, P: 1-19
Placental Expression of Angiopoietin-1, Angiopoietin-2 and Tie-2 during Placental Development in an Ovine Model of Placental Insufficiency-Fetal Growth Restriction

Amy S Erickson Hagen
Ryan J Orbus
Russell V Anthony
Research01 Dec 2005
Pediatric Research

Volume: 58, P: 1228-1232
The role of CARMA3 in regulating fibrosis to prevent hypertrophic cardiomyopathy

Yafeng Liu
Ganyi Chen
Zhibing Qiu
ResearchOpen Access06 Oct 2025
Cell Death Discovery

Volume: 11, P: 1-12
SBK3 suppresses angiotensin II-induced cardiac hypertrophy by regulating mitochondrial metabolism

Aihua Yang
Jiaxin Cao
Weizhong Zhu
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Tellurium-assisted growth of large-scale atom-thin insulating amorphous carbon on insulating substrates

Monolayer amorphous carbon (a-C) has attracted attention due to its structural and electronic properties, but its synthesis has so far required the use of metal substrates. Here, the authors report the Te-assisted growth of large-scale 2D a-C patterns on various insulating substrates, confirming their insulating properties in quantum tunnelling devices.

Ya Deng
Zihao Wang
Zheng Liu
ResearchOpen Access03 Oct 2025
Nature Communications

Volume: 16, P: 1-9
RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling

Vascular inflammation plays a key role in pathogenesis of major vascular diseases. Here the authors show that Regulator of G-Protein Signaling-1 (RGS1) controls macrophage function in the development of vascular inflammation that underlies atherosclerosis and abdominal aortic aneurysms in mice and humans.

Jyoti Patel
Eileen McNeill
Keith M. Channon
ResearchOpen Access18 Mar 2015
Nature Communications

Volume: 6, P: 1-11
Real world outcomes of faricimab in treatment resistant neovascular age-related macular degeneration among Asian patients

Elvine Zhong Oen Neo
Kevin Wei Onn Liang
Wei Kiong Ngo
ResearchOpen Access29 Sept 2025
Scientific Reports

Volume: 15, P: 1-8
Effects and mechanisms of trifolin on attenuating hypertension-induced vascular smooth muscle cell proliferation and collagen deposition in vivo and in vitro

Aling Shen
Meizhu Wu
Keji Chen
ResearchOpen Access09 May 2025
Scientific Reports

Volume: 15, P: 1-16
Angiopoietin/Tek Interactions Regulate MMP-9 Expression and Retinal Neovascularization

Arup Das
William Fanslow
Paul McGuire
Research01 Nov 2003
Laboratory Investigation

Volume: 83, P: 1637-1645
Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney

Oliver Domenig
Arndt Manzel
Marko Poglitsch
ResearchOpen Access21 Sept 2016
Scientific Reports

Volume: 6, P: 1-11
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

Masanori Asakura
Masafumi Kitakaze
Shigeki Higashiyama
Research01 Jan 2002
Nature Medicine

Volume: 8, P: 35-40
Angiotensin II represses Npr1 expression and receptor function by recruitment of transcription factors CREB and HSF-4a and activation of HDACs

Kiran K. Arise
Prerna Kumar
Kailash N. Pandey
ResearchOpen Access09 Mar 2020
Scientific Reports

Volume: 10, P: 1-17
Multivariate protein landscape of host response in hospitalised patients with suspected infection in the emergency department

Authors measure plasma proteins in a cohort of hospitalised patients presenting to the emergency department with suspected infection, revealing six discrete host response clusters that were driven by pathogen exposure and organ dysfunction, and had distinct clinical characteristics, hospital courses, and responses to treatment.

Pratik Sinha
Alexandra B. Spicer
Matthew M. Churpek
ResearchOpen Access22 Aug 2025
Nature Communications

Volume: 16, P: 1-12
Acute infusion of angiotensin II regulates organic cation transporters function in the kidney: its impact on the renal dopaminergic system and sodium excretion

Nicolás M. Kouyoumdzian
Natalia L. Rukavina Mikusic
Marcelo R. Choi
Research16 Sept 2020
Hypertension Research

Volume: 44, P: 286-298
All-trans retinoic acid inhibits the increases in fibronectin and PAI-1 induced by TGF-β1 and Ang II in rat mesangial cells

Xia Liu
Lei Lü
Yi-chun Zhu
Research01 Sept 2008
Acta Pharmacologica Sinica

Volume: 29, P: 1035-1041
Angiotensin II affects inflammation mechanisms via AMPK-related signalling pathways in HL-1 atrial myocytes

Nami Kim
Youngae Jung
Hyeon Soo Kim
ResearchOpen Access04 Sept 2017
Scientific Reports

Volume: 7, P: 1-12
Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells

Long term haematopoitic stem cells (LT-HSCs) are in a quiescent state during homeostasis, which is critical for their maintenance. Here, the authors show that Gal-3 expression in LT-HSCs is induced in response to Tie2 and Mpl and is both necessary and sufficient for LT-HSC quiescence through regulation of p21.

Weizhen Jia
Lingyu Kong
Nobuyuki Takakura
ResearchOpen Access09 Apr 2021
Nature Communications

Volume: 12, P: 1-17
JOSD2 inhibits angiotensin II-induced vascular remodeling by deubiquitinating and stabilizing SMAD7

Si-rui Shen
Zhu-qi Huang
Guang Liang
Research20 Jan 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1275-1288
ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation

C-Y Huang
W-W Kuo
C-Y Huang
Research02 May 2014
Cell Death & Differentiation

Volume: 21, P: 1262-1274
Synthetic angiotensin II peptide derivatives confer protection against cerebral and severe non-cerebral malaria in murine models

Adriana F. Silva
Marcelo D. T. Torres
Ana Acacia S. Pinheiro
ResearchOpen Access26 Feb 2024
Scientific Reports

Volume: 14, P: 1-9
Naringin attenuates angiotensin II induced cardiac hypertrophy by inhibiting carbonic anhydrase II

Mahendra Mahadevaswamy
G. P. Suchitha
Jalahalli M. Siddesha
ResearchOpen Access06 Apr 2025
Scientific Reports

Volume: 15, P: 1-14
Biomarker panels for improved risk prediction and enhanced biological insights in patients with atrial fibrillation

In atrial fibrillation patients, circulating biomarkers reflecting inflammation, myocardial injury, and coagulation improve prediction of stroke, heart failure, and bleeding, outperforming clinical scores and enhance risk stratification.”.

Pascal B. Meyre
Stefanie Aeschbacher
David Conen
ResearchOpen Access31 Jul 2025
Nature Communications

Volume: 16, P: 1-9
Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome

Loss of the metalloproteinase Adamts1 leads to aortic pathology in mice due to increased NOS2-dependent NO production. Decreased Adamts1 expression, associated with increased NOS2 expression, occurs in Marfan syndrome (MFS) mice and in MFS patients, and NOS2 inhibition prevents and reverses aortic pathology in MFS mice.

Jorge Oller
Nerea Méndez-Barbero
Juan Miguel Redondo
Research09 Jan 2017
Nature Medicine

Volume: 23, P: 200-212
Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ

Body fluid conditions are continuously monitored in the brain in order to regulate thirst and salt appetites. Through a combination of optogenetics and electrophysiology, the authors reveal distinct neural mechanisms in the subfornical organ for generating appropriate water- and salt-intake behaviors according to body fluid conditions.

Takashi Matsuda
Takeshi Y Hiyama
Masaharu Noda
Research19 Dec 2016
Nature Neuroscience

Volume: 20, P: 230-241
Sequential, timely and controlled expression of hVEGF₁₆₅ and Ang-1 effectively improves functional angiogenesis and cardiac function in vivo

H Zhang
Y L Yuan
Z M Zhang
Research21 Mar 2013
Gene Therapy

Volume: 20, P: 893-900
Altered levels of angiogenin and tRNA-derived fragments associate with severe asthma

Clara Claus
Julieta B. Grosso
Silvana V. Spinelli
ResearchOpen Access29 May 2025
Scientific Reports

Volume: 15, P: 1-13
Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc

Back pain and sciatica are often caused by intervertebral disc degeneration. Sakai and colleagues identify a subset of nucleus pulposus progenitor cells from the intervertebral disc and show that loss of these progenitor cells correlates with ageing and intervertebral disc degeneration.

Daisuke Sakai
Yoshihiko Nakamura
Joji Mochida
ResearchOpen Access11 Dec 2012
Nature Communications

Volume: 3, P: 1-11

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