Search

Vortices in an electron fluid are directly observed in a para-hydrodynamic regime in which the spatial diffusion of electron momenta is enabled by small-angle scattering rather than electron–electron scattering.

ANKLE1 senses DNA tension and negative supercoiling, enhancing cleavage of stretched, supercoiled DNA to resolve chromatin bridges, highlighting its unique mechanosensitive role in maintaining genome stability during cell division.

One of three back-to-back papers to show that dosage of BACH2 can modulate T cell differentiation and function and how we might apply this to enhance CAR T cell therapies for cancer.

A recently developed class of magneto-sensitive fluorescent proteins are engineered to alter the properties of their response to magnetic fields and radio frequencies, enabling multimodal sensing of biological systems.

The Drosophila egg-deposition motor programme is initiated once a rise-to-threshold process hits a threshold, and subthreshold variation in this process regulates the time spent considering options.

Structural, genetic, functional and biochemical analyses of the complex flagellar motor of Campylobacter jejuni reveal structural adaptations with an ancient origin also found more widely across bacterial species, including elements exapted from the type IV pilus machinery.

Cannabis exposure is a critical concern, particularly during adolescence. This study shows that tetrahydrocannabinol-induced cognitive deficits are mediated by a specific astrocytic ensemble in the nucleus accumbens whose manipulation prevents and reverses these effects.

This digital PCR device arrays samples into one million small-volume reactors, achieving a dynamic range of 10⁷, measurement precision better than 1% and the ability to detect single-nucleotide variants present at less than 1:100,000.

Borsa et al. show that asymmetric T cell division after activation requires autophagy to promote mitochondrial turnover, with T cells inheriting older mitochondria showing decreased degradation, reduced memory potential and altered metabolism.

The vagus nerve is known to promote rest and digest, to counter physiologic stresses. Here, authors show that insulin signaling plays a critical role in optimizing autonomic function to maintain metabolic and inflammatory homeostasis.

Botulinum toxins vary in oral toxicity, but the reasons are unclear. Here, the authors show that the differences can be due to variations in one of the toxin’s components, the hemagglutinin complex, which influence mucin binding and mucus layer penetration

Water scarcity is a global challenge due to climate change and population growth. Here, authors developed an asymmetric tapered multistage solar still that optimizes mass transfer equilibrium, achieving ultrahigh water production and efficiency.

Cell death induced by metal ions is promising for cancer immunotherapy but sometimes limited by effective loading/release into tumor sites. Here this group reports a binary mineral nanoparticles incorporating both Ca2+ and Na+ ions to enhance the cytotoxic effects of ion interference in cancer immunotherapy.

Natural products have historically made a major contribution to pharmacotherapy, but also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization. This Review discusses recent technological developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — that are enabling a revitalization of natural product-based drug discovery.

Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous remodelling of cellular overlaps that maintain vessel integrity.

The current prevailing view is that body plans of sponges and other animals cannot be compared. Here, the authors identify developmental regulatory genes in the calcisponge, Sycon ciliatum, and report similar developmental gene expression between sponges and cnidarians, which suggests that their body plans are homologous.

Neural basis of decision-making is not fully understood. Here authors show that mouse prefrontal neurons encode history-specific rewards and choices. However, their influence is gated by task structure and timing, affecting decisions primarily in variable interval tasks and when temporal delays separate events.

Liquid crystals confined to micrometre-sized geometries can be well described by a continuum theory, where the size effect of constituent mesogens is negligible. Here, the authors show how the continuum theory breaks down in colloidal liquid crystal, leading to the formation of defect-mediated domains.

Measurements in three taxa with the characteristics of vertebrate ancestors (lamprey ammocoetes, amphioxus and acorn worms) suggest that gas exchange at gills has a vertebrate origin, but that ion regulation at gills has an earlier and possibly stem deuterostome origin.

Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNA^Ala mutation (m.5019A>G) in mice and demonstrate that macrophages carrying this mutation display altered function and metabolism in vitro, along with increased type I IFN release following LPS challenge in vivo.

Alström syndrome (AöS) is a rare genetic disorder characterized by metabolic problems. Here, the authors show that in AöS models, defects in cilia and autophagy lead to ACBP accumulation, which drives obesity. An anti-ACBP antibody reduces weight gain and metabolic dysfunction, highlighting ACBP as a therapeutic target for this ciliopathy.

The transcriptional regulation of oligodendrocytes has an essential role in myelin formation and maintenance. Here, the authors identify the transcription factor Tfii-i as a regulator of myelin genes expression in the nervous system and show that its loss enhances myelin thickness and nerve conduction.

A COVID-19 test implemented in an automated microfluidic device and leveraging isothermal RNA amplification followed by T7 transcription and Cas13-mediated cleavage of a quenched fluorophore rapidly detects SARS-CoV-2 RNA in saliva samples.

Schiattarella and colleagues propose a framework linking heart failure with preserved ejection fraction and metabolic dysfunction-associated steatotic liver disease as interconnected syndromes rather than coincidental comorbidities. The authors delineate shared metabolic, inflammatory and endocrine drivers and propose a shift towards coordinated strategies and integrated clinical algorithms to improve prevention, risk stratification, early detection and co-management of these disorders.

A 15-year prospective cohort study found that during times of social unrest in Hong Kong, people experienced more conflicts with family and friends and this coincided with the use of social media—these factors were also associated with higher levels of depression.

End-stage heart failure remains a major clinical challenge with limited effective treatments. Here, the authors present a concept for a soft robotic total artificial heart with a biocompatible inner lining that shows native-like functions

Field data reveal that thaw slumps on the Tibetan Plateau initially turn alpine grasslands from CO₂ sinks into sources by exposing bare ground; as slumps stabilize and vegetation returns, CO₂ exchange recovers toward a sink.

Here, the authors reveal that protozoal communities shape rumen microbiome structure, offering fresh insights into how these complex communities coordinate essential metabolic tasks across multiple microbial domains.

An intestinal organoid model recapitulates human microfold (M) cell function and transcriptomic profiling and biochemical assays demonstrate that M cells uptake and present antigens to the immune system via the class II major histocompatibility complex.

Here they demonstrate a therapeutic intervention elevating levels of CYP450-derived lipids to control the expansion of intermediate monocytes in tissue and peripheral blood, presenting a first in class therapeutic approach for treating chronic inflammatory disease.

Biofilms are specialized environments where one might predict that evolution demands intense interactions between bacteria. However, by using two species, this paper demonstrates that genomic changes occur to favour species working together to enhance fitness.

Using seven generations of selected zebrafish (Danio rerio), the authors consider the trade-offs and mechanisms behind evolution of warming tolerance. They show unexpected improvements in cooling tolerance in warming-adapted fish, and highlight mechanistic insights behind warming tolerance.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Smart microscopy is an emerging technology which integrates real-time analysis with adaptive acquisition to enhance imaging efficiency. Here the authors introduce “outcome-driven microscopy,” an approach that uses optogenetics and real-time feedback to control cell behaviour and protein dynamics.

The complement cascade is increasingly recognized in the brain. Here, with MERFISH, the authors showed developmentally regulated brain endogenous expression of complement genes and a potential role of the alternative pathway in brain development.

Gas evolution severely limits the performance of LiFe_xMn_1−xPO₄ batteries, yet its mechanisms remain unclear. Now it has been shown that CO₂ originates mainly from the cathode and H₂ from Mn/Fe-catalysed reactions at the anode, while a uniform carbon coating effectively suppresses metal dissolution and stabilizes cycling.

Most active particles studied to date lack the ability to undergo controlled shape transformations and control over their propulsion in response to environmental stimuli. Here, the authors present a class of active particles made from stimuli-responsive materials that exhibit fully reversible shape-dependent propulsion.

A microcosm experiment replicated across 14 laboratories shows that deliberate inclusion of genetic variation enhances the reproducibility of an ecological study.

An in-depth analysis of tissue biopsies from patients with multiple myeloma and CAR T cell therapy-associated immune-related adverse events (CirAEs) after treatment with commercial BCMA-targeted CAR T cell therapy shows that CD4⁺ CAR T cells mediate off-tumor toxicities and that high CD4:CD8 ratio at apheresis, robust early CAR T cell expansion, ICANS and ciltacabtagene autoleuce treatment are independently associated with the development of CirAEs.

Signalling endosomes are known to be essential for neuronal survival. Here the authors show that, in cultured hippocampal neurons and live Drosophilalarval motor neurons, neuronal activity increases the retrograde flux of signalling endosomes, and this coupling depends on TrkB activation.

In Alzheimer's disease, tau spreads throughout the brain, however the nature of the tau species propagating from one neuron to another is not known. Here, Takeda et al. identify a rare, high-molecular-weight tau as the primary species taken up and transferred between synaptically connected neurons.

Cities serve as climate change laboratories for phenology studies. Here, the authors show that results of such studies should be interpreted with caution, as urban-rural phenology gaps are primarily driven by species composition differences rather than temperature differences.

Optical dating of sediments from Denisova Cave establishes a chronology for its Pleistocene deposits and the associated artefacts, hominin remains and environmental records, which date to between about 300,000 and 20,000 years ago.