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High-density multimodal soft bioelectronic fibres provide a platform for minimally invasive implantable electronics, where diverse sensing and stimulation functionalities can be effectively integrated.

Confining electrons to two dimensions can drastically alter the way they interact with each other. Here, the authors show that electrons in quantum wells can form into two distinct solid-like phases when placed in a large magnetic field.

Analysis of soundscape data from 139 globally distributed sites reveals that sounds of biological origin exhibit predictable rhythms depending on location and season, whereas sounds of anthropogenic origin are less predictable. Comparisons between paired urban–rural sites show that urban green spaces are noisier and dominated by sounds of technological origin.

A special class of topological Weyl semimetal state is predicted without respecting Lorentz symmetry. Here, Jianget al. report direct visualization of the unique surface Fermi arcs of MoTe₂, confirming its type-II topological Weyl semimetal nature.

Sotos syndrome is an growth syndrome characterized by advanced growth in childhood, characteristic facial appearance and intellectual disability. Here the authors identify a genome-wide DNA methylation signature that accurately diagnoses Sotos Syndrome and distinguishes it from similar conditions.

John Perry and colleagues report the results of a large genome-wide association study meta-analysis to identify variants influencing age at natural menopause. They identify 54 independent signals and find enrichment near genes involved in delayed puberty and DNA damage response.

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.

Soft conducting polymer electrodes allowing for the continuous and precise localization of a target nerve during microsurgeries led to improved post-operative prognoses after tumour-resection surgeries in rats.

Metallic oxide SrNbO₃has been identified as an efficient hydrogen evolution photocatalyst. Here, Venkatesan and co-workers show that its visible light absorption stems from plasmon resonance, thanks to its large carrier density (despite a large 4.1 eV bandgap), as opposed to from an interband transition.

NeuroString, a tissue-like biological interface created by laser patterning of polyimide into a graphene/nanoparticle network embedded in an elastomer, is introduced, allowing in vivo real-time detection of neurotransmitters in the brain and gut.

The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

A single-cell transcriptomic analysis of 63 patients with colorectal cancer classifies tumor cells into two epithelial subtypes. An improved tumor classification based on epithelial subtype, microsatellite stability and fibrosis reveals differences in pathway activation and metastasis.

By integrating wireless stretchable on-skin sensor tags and flexible readout circuits attached to textiles using an unconventional radiofrequency identification design, a body area sensor network can be created that can continuously analyse a person’s pulse, breathing and body movement.

A material design strategy and fabrication process is described to produce all-polymer light-emitting diodes with high brightness, current efficiency and good mechanical stability, with applications in skin electronics and human–machine interfaces.

A stretchable anode, cathode, semiconductor and current collector have been developed to create stretchable diodes that can operate at megahertz frequencies for use in wirelessly operated, skin-like wearable electronics.

Next-generation skin-inspired electronics require enhanced mechanical robustness and device complexity including elasticity, solvent resistance, and facile patternability. Here, the authors show a molecular design concept that simultaneously achieves all these requirements by covalently linking an in-situ formed rubber matrix with polymer electronic materials.

Although ageing is the most important risk factor for chronic ailments, effective interventions remain rare. Here, the authors identify the flavonoid 4,4’-dimethoxychalcone and demonstrate that it extends lifespan and promotes health in multiple organisms by inducing autophagy.

Conductive and elastic hydrogel-based microelectronic arrays with high current-injection density and low interfacial impedance with tissue enable the localized low-voltage electrical stimulation of the sciatic nerve in live mice.

Shyam Prabhakar, Paul Robson, Iain Beehuat Tan and colleagues characterize the cellular heterogeneity of colorectal tumors and their microenvironment on the basis of single-cell RNA–seq data analyzed with their newly developed clustering algorithm, reference component analysis (RCA). Their analyses identify two subtypes of cancer-associated fibroblasts and further divide tumors into subgroups with divergent survival probabilities.

Engineering of the interfacial properties between a semiconducting thin film and a stretchable substrate using tough interfacial bonding enables a notable delay in microcrack formation.

Viscoplastic electronic devices adapt as nerves enlarge in growing animals.

A scalable process is described for fabricating skin-like electronic circuitry that can be bent and stretched while retaining desirable electronic functionality.

Self-incompatibility is an important mechanism used in many species to prevent inbreeding by ensuring rejection of 'self' pollen. The cloning of three alleles of a highly polymorphic pollen-expressed gene, PrpS (Papaver rhoeas pollen S), now provides evidence that it encodes the pollen S locus determinant and adds to our knowledge of the evolution of cell–cell recognition systems.

The International Stem Cell Initiative compares 125 ethnically diverse human embryonic stem cell lines at early and late passage. Data on karotype, single-nucleotide polymorphisms and methylation shed light on how the cells adapt to long-term culture.

Cachexia-inducing tumors release complex factors that promote the increased uptake and burning of fats by muscle, resulting in muscle atrophy—a process that can be blocked if fatty acid oxidation is pharmacologically inhibited.